2005
DOI: 10.1152/ajprenal.00133.2004
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Abstract: The end product of human purine metabolism is urate, which is produced primarily in the liver and excreted by the kidney through a well-defined basolateral blood-to-cell uptake step. However, the apical cell-to-urine efflux mechanism is as yet unidentified. Here, we show that the renal apical organic anion efflux transporter human multidrug resistance protein 4 (MRP4), but not apical MRP2, mediates ATP-dependent urate transport via a positive cooperative mechanism (K(m) of 1.5 +/- 0.3 mM, V(max) of 47 +/- 7 pm… Show more

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Cited by 207 publications
(155 citation statements)
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“…The recently identified human urate transporters, such as OAT1 and OAT3, play a critical role in this process. 18,19 They are localized on the basolateral membrane of epithelial cells, with the ability to transport uric acid from the renal interstitium into tubular epithelial cells, which then secrete it into the renal tubular lumen. Therefore, increased OAT1 and OAT3 expression would promote uric acid secretion.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The recently identified human urate transporters, such as OAT1 and OAT3, play a critical role in this process. 18,19 They are localized on the basolateral membrane of epithelial cells, with the ability to transport uric acid from the renal interstitium into tubular epithelial cells, which then secrete it into the renal tubular lumen. Therefore, increased OAT1 and OAT3 expression would promote uric acid secretion.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, OAT1 and OAT3 may play a pivotal role in uric acid transport and metabolism. [17][18][19] HN is characterized by glomerular hypertension, arteriolosclerosis, and tubulointerstitial fibrosis. Traditionally, hyperuricemia has been assumed to induce renal disease through deposition of uric acid crystals in the collecting duct of the nephron in a manner similar to gouty arthropathy.…”
mentioning
confidence: 99%
“…However, in spite of these in vitro evidences, there is still no direct evidence that UAT transports urate in vivo. In addition, the multidrug resistance protein-4 (MRP4) has been also identified in the apical membrane of renal proximal tubular cells as an ATPdependent unidirectional efflux pump for urate [6].…”
Section: Regulation Of Urate In the Kidneymentioning
confidence: 99%
“…1A). In addition, ABCG2-expressing oocytes showed lower urate concentrations than oocytes expressing the known urate efflux transporter MRP4 (7). The reduced urate accumulation in ABCG2-expressing oocytes was absent in the presence of fumitremorgin C (FTC), a specific ABCG2 inhibitor, or after introduction of a mutation in ABCG2 (187T) that is known to disrupt transport of chemotherapeutic agents (5, 6) (Fig.…”
mentioning
confidence: 99%