Human Myelogenous (Ph
            1
            +) Leukemia Cell Line:  Into Athymic Mice
            2

Lozzio, Bismarck B.; Lozzi, C B; Machado, Emilio A.

doi:10.1093/jnci/56.3.627

Cited by 44 publications

(5 citation statements)

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“…In vivo models would aid in the development of treatment strategies and further our understanding of leukemic transformation and progression. Subcutaneous transplantation of lymphoid and myeloid cell lines (2)(3)(4)(5)(6)(7)(8)(9), lymphomas (8), or primary patient material (2) into nude mice produces myelosarcomas or localized solid tumors (10) uncharacteristic of the primary leukemia. The growth of one human leukemia cell line in the hematopoietic tissues of nude mice has been described (11).…”

mentioning

confidence: 99%

A Model of Human Acute Lymphoblastic Leukemia in Immune-Deficient SCID Mice

Kamel‐Reid

Letarte

Sirard

et al. 1989

Science

228

103

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A human acute lymphoblastic leukemia (ALL) cell line that was transplanted into immune-deficient SCID mice proliferated in the hematopoietic tissues, invaded various organs, and led to the death of the mice. The distribution of leukemic cells in SCID mice was similar to the course of the disease in children. A-1 cells marked with a retrovirus vector showed clonal evolution after the transplant. SCID mice that were injected with bone marrow from three patients with non-T ALL had leukemic cells in their bone marrow and spleen. This in vivo model of human leukemia is an approach to understanding leukemic growth and progression and is a novel system for testing new treatment strategies.

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mentioning

confidence: 99%

A Model of Human Acute Lymphoblastic Leukemia in Immune-Deficient SCID Mice

Kamel‐Reid

Letarte

Sirard

et al. 1989

Science

228

103

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“…One of the earliest attempts to model human CML in immunodeficient mouse models dates back to the late '70s, where the BCR-ABL + cell line K562 was injected into nude mice which grew as solid vascularized tumors containing cells like those seen in the patient and in the cultures [43]. Similar observations with the K562 cell line were later reported by Caretto and colleagues [44].…”

Section: Xenotransplant Modelsmentioning

confidence: 75%

Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models

Sontakke

Jaques

Vellenga

et al. 2016

Stem Cells International

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Over the past years, a wide variety of in vivo mouse models have been generated in order to unravel the molecular pathology of Chronic Myeloid Leukemia (CML) and to develop and improve therapeutic approaches. These models range from (conditional) transgenic models, knock-in models, and murine bone marrow retroviral transduction models followed by transplantation. With the advancement of immunodeficient xenograft models, it has become possible to use human stem/progenitor cells for in vivo studies as well as cells directly derived from CML patients. These models not only mimic CML but also have been instrumental in uncovering various fundamental mechanisms of CML disease progression and tyrosine kinase inhibitor (TKI) resistance. With the availability of iPSC technology, it has become feasible to derive, maintain, and expand CML subclones that are at least genetically identical to those in patients. The following review provides an overview of all murine as well as human xenograft models for CML established till date.

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“…This study provides proof of the persistence of these leukemic stem cells even in patients who have received TKI therapy for years. Primary patient samples and cell lines established from CML patients in various phases have been engrafted into athymic mice [123], SCID mice [124], and NOD/SCID mice [125]. The use of mosaic, transgenic, and xenograft models has provided invaluable insights into the molecular pathology of this leukemia.…”

Section: Notch1mentioning

confidence: 99%