Human Metapneumovirus and Lower Respiratory Tract Disease in Otherwise Healthy Infants and Children

Williams, John V.; Harris, Paul A.; Tollefson, Sharon J.; Halburnt-Rush, Lisa L.; Pingsterhaus, Joyce M.; Edwards, Kathryn M.; Wright, Peter F.; Crowe, James E.

doi:10.1056/nejmoa025472

Cited by 834 publications

(944 citation statements)

References 25 publications

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“…However, our results show that LRTI associated with viral co-infection does not result in a higher incidence of severe syndromes compared to infection with HRV alone. Other groups have reported similar results (Williams et al 2004, Choi et al 2006, Calvo et al 2007, Louie et al 2009). …”

Section: Discussionsupporting

confidence: 72%

Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

Paula

Carneiro

Yokosawa

et al. 2011

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 72%

Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

Paula

Carneiro

Yokosawa

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…The clinical symptoms and laboratory findings associated with hMPV infection exhibit a spectrum virtually indistinguishable from those associated with RSV disease. With one possible exception, RSV peaks from December to February, while hMPV is increasingly detected from January to April (14,24). However, it is generally accepted that during the respiratory illness season, laboratories must take into account the existence of both viruses.…”

Section: Discussionmentioning

confidence: 99%

“…They are enveloped, single-stranded, negative-sense RNA viruses. Epidemiological studies indicate that, like RSV, hMPV is a significant human respiratory pathogen with a worldwide distribution (6,16,23,24). Indeed, hMPV appears to affect many of the same subpopulations and cause clinical manifestations, including upper respiratory tract infections, bronchiolitis, and pneumonia, similar to those caused by RSV, although they are of lesser severity (24).…”

mentioning

confidence: 99%

Prospective Evaluation of Rapid Antigen Tests for Diagnosis of Respiratory Syncytial Virus and Human Metapneumovirus Infections

Aslanzadeh

Zheng

Li³

et al. 2008

J Clin Microbiol

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Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are two important viral pathogens that cause respiratory tract infections in the pediatric population. The rapid detection of these agents allows the prompt isolation and treatment of infected patients. In the present prospective study, we evaluated the performances of four rapid antigen detection assays, including a rapid chromatographic immunoassay ( , the CIA had a sensitivity of 79.8% and a specificity of 89.5%. The RSV DFA with Bartels reagents showed a sensitivity of 94.1% and a specificity of 96.8%. For hMPV, the sensitivity and specificity were 62.5% and 99.8%, respectively, for the DHI DFA and 63.2% and 100%, respectively, for the Imagen DFA. The hands-on and test turnaround times for CIA were 10 and 30 to 60 min, respectively, and the hands-on and test turnaround times for the RSV and hMPV DFAs were 30 and 105 min, respectively. We conclude that while the RSV CIA is user-friendly, it lacks sensitivity and specificity, especially during off-peak months. In contrast, the RSV DFA is more sensitive and specific, but interpretation of its results is subjective and it demands technical time and expertise. Similarly, both hMPV DFAs are highly specific in comparison to the results of RT-PCR, but their sensitivities await further improvements.Respiratory syncytial virus (RSV) is the single most important cause of respiratory tract infections in children. It is estimated that each year in the United States, 100,000 hospitalizations and 4,500 deaths are attributed to RSV infection (20). Similar to RSV, human metapneumovirus (hMPV), identified in The Netherlands in 2001, is thought to cause upper and lower respiratory tract infections in children (23). Both RSV and hMPV are members of the family Paramyxoviridae (20). They are enveloped, single-stranded, negative-sense RNA viruses. Epidemiological studies indicate that, like RSV, hMPV is a significant human respiratory pathogen with a worldwide distribution (6,16,23,24). Indeed, hMPV appears to affect many of the same subpopulations and cause clinical manifestations, including upper respiratory tract infections, bronchiolitis, and pneumonia, similar to those caused by RSV, although they are of lesser severity (24). Both RSV and hMPV have been shown to infect the majority of children by the age of 5 years. Moreover, reinfections have been observed in all age groups (4).The laboratory diagnosis of RSV and hMPV infections can be made by virus isolation, detection of viral antigens, amplification of viral RNA by molecular techniques, demonstration of a rise in serum antibody levels, or a combination of these approaches (7,9,13,15,21,26). The use of rapid tests for the diagnosis of RSV and hMPV infections allows implementation of appropriate infection control measures, thus reducing nosocomial spread, and is useful for consideration of timely treatment with antiviral agents (8,12). The clinical and financial benefits of the rapid detection of RSV in respiratory specimens have been demonstrated in several...

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“…Accumulating evidence has shown that HMPV has a worldwide distribution and seasonal circulation, that it is a common respiratory pathogen in childhood, and that it contributes substantially to the aetiology and pathogenesis of lower respiratory tract infection (LRTI) [2][3][4][5][6][7]. Numerous studies have focused on the clinical and epidemiological characteristics of HMPV infection, but few have been population based, and consequently the available information on the incidence and burden of this disease remains scarce.…”

Section: Introductionmentioning

confidence: 99%

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

et al. 2008

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SUMMARYNumerous studies have been published on human metapneumovirus (HMPV) infection, but few have been population based. The main aim of this study was to estimate the incidence rate of hospitalization for community-acquired HMPV infection in infants and children aged <3 years. Between July 2004 and June 2007, 796 episodes (742 patients) of community-acquired acute respiratory infection were hospitalized. HMPV was detected in 90 episodes (11 . 3%). Fifty-nine episodes occurred in infants aged <1 year. The mean length of hospital stay was 6 . 2 days (range 2-31 days). Thirteen children required admission to the intensive care unit. Viral co-infections were detected in 46 episodes (51 . 1%). The incidence rate of hospitalization per 1000 inhabitants was 2 . 6 (95 % CI 2 . 1-3 . 2), lower than that for respiratory syncytial virus, but higher than that observed for the influenza and parainfluenza viruses. HMPV is a major respiratory pathogen that leads to a high hospitalization rate.

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Human Metapneumovirus and Lower Respiratory Tract Disease in Otherwise Healthy Infants and Children

Abstract: Human metapneumovirus infection is a leading cause of respiratory tract infection in the first years of life, with a spectrum of disease similar to that of respiratory syncytial virus.

Cited by 834 publications

References 25 publications

Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

Prospective Evaluation of Rapid Antigen Tests for Diagnosis of Respiratory Syncytial Virus and Human Metapneumovirus Infections

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

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