Human Intraocular Filariasis Caused by<i>Pelecitus</i>sp. Nematode, Brazil

Bain, O.; Otranto, Domenico; Diniz, Daniel Guerreiro; Santos, Jeannie Nascimento dos; Oliveira, Norimar Pinto de; Almeida, Izabela; Almeida, Rafael Negrão Frota de; Almeida, Luciana Negrão Frota de; Dantas‐Torres, Filipe; Sobrinho, Edmundo Frota de Almeida

doi:10.3201/eid1705.101309

Cited by 27 publications

(24 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In South America, fifty sporadic cases have been reported: pulmonary (Venezuela, Colombia, Brazil, Argentina) and subcutaneous/ocular nodules (Brazil, Chile) [8,51,52]. D. immitis implicated in human ocular dirofilariasis was classified as a more virulent strain [51]. Fortunately, the phylogenetic analysis we conducted indicated that it is not the virulent D. immitis (Figures 3 and 4) which could explain the lower prevalence of human cases [39].…”

Section: Discussionmentioning

confidence: 86%

“…Since humans can be infected, doctors could be confronted with this parasitosis, which is mainly characterized by the presence of pulmonary nodules. In South America, fifty sporadic cases have been reported: pulmonary (Venezuela, Colombia, Brazil, Argentina) and subcutaneous/ocular nodules (Brazil, Chile) [8,51,52]. D. immitis implicated in human ocular dirofilariasis was classified as a more virulent strain [51].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Detection of Canine Vector-Borne Filariasis and Their Wolbachia Endosymbionts in French Guiana

et al. 2020

View full text Add to dashboard Cite

In French Guiana, canine heartworm disease is well known, but the diversity of filarial parasites of dogs remains largely unknown. A total of 98 canine blood samples from Cayenne and Kourou were assessed by a blood wet mount preparation, heartworm antigen test and molecular exploration of filarioid and Wolbachia DNAs, followed by a multiplex species-specific qPCR’s identification and a subsequent sequencing analysis. Thereafter, a phylogeny based on maximum likelihood was carried out to facilitate specific identification. Five dogs were microfilaremic. Heartworm antigens were detected in 15 (15.3%) dogs. Of these, six (6.1%) were considered as occult infections as neither microfilariae nor Dirofilaria immitis DNA were detected. The 11 (11.2%) D. immitis isolates corresponded to a low virulent strain. Six of the D. immitis isolates were positive for Wolbachia endosymbionts of D. immitis belonging to the clade C DNA. Acanthocheilonema reconditum DNA was detected in 3 (3.1%) samples. Of these latter, one was found co-infected with the Brugia sp. genotype and the DNA of the clade D of the Wolbachia endosymbiont of Brugia species. This latter was also detected in two filarioid DNA-free samples. Finally, two samples were positive for Cercopithifilaria bainae genotype, which is distinct from those identified in Europe. The present study highlights the urgent need to implement chemoprophylaxis associated with anti-Wolbachia drugs to control these potential zoonoses.

show abstract

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Detection of Canine Vector-Borne Filariasis and Their Wolbachia Endosymbionts in French Guiana

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Many cases of zoonoses caused by mammalian filariae belonging to the two subfamilies Onchocercinae and Dirofilariinae have been identified [30]. Two rare zoonoses have also been described: one caused by Meningonema peruzzii, from the subfamily Splendidofilariinae [31], and another caused by Pelicitus sp., an avian filaria [32].…”

Section: Biology Of Filariae and Their Endosymbiont Wolbachiamentioning

confidence: 99%

The symbiotic role of Wolbachia in Onchocercidae and its impact on filariasis

Bouchery

Lefoulon

Karadjian

et al. 2013

Clinical Microbiology and Infection

View full text Add to dashboard Cite

Symbiotic associations between eukaryotes and microorganisms are frequently observed in nature, and range along the continuum between parasitism and mutualism. The genus Wolbachia contains well-known intracellular bacteria of arthropods that induce several reproductive phenotypes that benefit the transmission of the bacteria. Interestingly, Wolbachia bacteria have been found in the Onchocercidae, a family of filarial nematodes, including species that cause human filarial diseases, e.g. lymphatic filariasis and onchocerciasis. The endosymbiont is thought to be mutualistic in the Onchocercidae, and to provide essential metabolites to the filariae. Currently, Wolbachia bacteria are targets of antibiotic therapy with tetracyclines, which have profound effects on the development, viability and fertility of filarial parasites. This overview article presents the Onchocercidae and Wolbachia, and then discusses the origin and the nature of the symbiosis. It highlights the contribution of Wolbachia to the survival of the filariae and to the development of pathology. Finally, the infection control implications for filariases are debated. Potential directions for future research are also discussed.

show abstract

“…[4-7]. The life cycles and the animal reservoir hosts for many of these species are still poorly known.…”

Section: Introductionmentioning

confidence: 99%

Human ocular filariasis: further evidence on the zoonotic role of Onchocerca lupi

et al. 2012

Self Cite

View full text Add to dashboard Cite

BackgroundAmong ocular vector-borne pathogens, Onchocerca volvulus, the agent of the so-called “river blindness”, affects about 37 million people globally. Other Onchocerca spp. have been sporadically reported as zoonotic agents. Cases of canine onchocerciasis caused by Onchocerca lupi are on the rise in the United States and Europe. Its zoonotic role has been suspected but only recently ascertained in a single case from Turkey. The present study provides further evidence on the occurrence of O. lupi infesting human eyes in two patients from Turkey (case 1) and Tunisia (case 2). The importance of obtaining a correct sample collection and preparation of nematodes infesting human eyes is highlighted.MethodsIn both cases the parasites were identified with morpho-anatomical characters at the gross examination, histological analysis and anatomical description and also molecularly in case 1.ResultsThe nematode from the first case was obviously O. lupi based on their morphology at the gross examination, histological analysis and anatomical description. In the second case, although the diagnostic cuticular characters were not completely developed, other features were congruent with the identification of O. lupi. Furthermore, the morphological identification was also molecularly confirmed in the Turkish case.ConclusionsThe results of this study suggest that O. lupi infestation is not an occasional finding but it should be considered in the differential diagnosis of other zoonotic helminths causing eye infestation in humans (e.g., D. immitis and Dirofilaria repens). Both cases came from areas where no cases of canine onchocerciasis were previously reported in the literature, suggesting that an in depth appraisal of the infestation in canine populations is necessary. Physicians and ophthalmologists are advised on how to preserve nematode samples recovered surgically, to allow a definitive, correct etiological diagnosis.

show abstract

Human Intraocular Filariasis Caused byPelecitussp. Nematode, Brazil

Cited by 27 publications

References 14 publications

Detection of Canine Vector-Borne Filariasis and Their Wolbachia Endosymbionts in French Guiana

Detection of Canine Vector-Borne Filariasis and Their Wolbachia Endosymbionts in French Guiana

The symbiotic role of Wolbachia in Onchocercidae and its impact on filariasis

Human ocular filariasis: further evidence on the zoonotic role of Onchocerca lupi

Contact Info

Product

Resources

About