volume 66, issue 6, P3531-3537 1992
DOI: 10.1128/jvi.66.6.3531-3537.1992
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Abstract: We describe human immunodeficiency type 2 (HIV-2) strains which induce cell-to-cell fusion and infect certain CD4-human cell lines. Soluble CD4 (sCD4) induces or enhances fusion by most HIV-2 strains tested. Soluble CD4-immunoglobulin G chimeras and conjugates of sCD4 and antibody to the third domain of CD4 block HIV-2 fusion of CD4-cells. We conclude that HIV-2 can enter CD4-cells via an alternative cell surface receptor to CD4. While some strains entered efficiently, others retained a dependency on an intera…

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