B M Blumberg, L G Epstein, Y Saito, D Chen, L R Sharer, R Anand
Abstract:The role of the nefgene in human immunodeficiency virus type 1 (HIV-1) infection is poorly understood. To provide a basis for studies on the role of nef in AIDS, we used targeted polymerase chain reaction amplification and DNA sequencing to determine the structure of nefgenes in pathologic tissue from HIV-l-infected children and adults. We find that the nef reading frame is open in 92% of clones derived from both brain and lymphocytic tissue of children, suggesting that nef is expressed in these tissues. One H…
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