1992
DOI: 10.1590/s0074-02761992000800014 View full text |Buy / Rent full text
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Abstract: Schistosoma mansoni infected Kenyan patients were treated and the intensities of their reinfections were followed over the next two years. In addition, their pre- and six month post-treatment serum levels of IgG1-4, IgM, and IgE, specific for schistosomula, egg and adult worm, were measured in ELISA. No reinfection took place before six months post-treatment. Reinfection intensities varied with age; the younger children becoming reinfected at significantly higher intensities than older individuals. When antibo… Show more

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“…Specific IgE, interacting with eosinophils and phagocytic cells, has been demonstrated to be effective in schistosomula destruction in vitro (6-8, 10, 12, 13, 15) and may be an important immune defense mechanism in the skin, where these cell types are found at the time of cercarial penetration. The majority of studies done with subjects from areas of endemicity support a role for IgE in resistance to S. mansoni infection (22,24,25,28,56,57). In the present study, the levels of SWAP-specific IgE were not correlated with infection levels.…”
Section: Vol 68 2000 Immune Response To S Mansoni Vaccine Candidatcontrasting
“…Although human immune responses to S. mansoni have been studied extensively, the mechanism by which humans resist schistosome infection are still unclear. Data from two different research groups in areas of endemicity in Kenya and Brazil have shown an association between resistance to reinfection and high levels of specific IgE and high IgE-to-IgG4 ratios (22,24,25,28,56,57). Other studies in two areas of endemicity in Minas Gerais, Brazil, have described subjects who exhibit complete resistance to infection (16).…”
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“…H igh levels of serum parasite-specific IgE are associated with resistance to human schistosomiasis, but the functional significance is undefined (1)(2)(3)(4). Indeed, the bona fide roles of IgE in the human immune system remain elusive.…”
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“…One such pattern is the distribution of immune responses across different ages in a host population. For both Schistosoma mansoni and S. haematobium responses directed against egg antigen, levels of IgE have been shown to increase with age, those of IgA, IgM and IgG2 have been shown to decrease with age, while levels of IgG1 and IgG3 have been shown to either increase or decrease (Demeure et al 1983, Butterworth et al 1988, Hagan et al 1991, Dunne et al 1992a,b, Grogan et al 1996, Ndhlovu et al 1996, Mutapi et al 1997, Webster et al 1997. The explanations for these patterns have been controversial.…”
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