2005
DOI: 10.1099/mic.0.28121-0
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Human hololactoferrin: endocytosis and use as an iron source by the parasite Entamoeba histolytica

Abstract: Entamoeba histolytica is an enteric protozoan that exclusively infects human beings. This parasite requires iron for its metabolic functions. Lactoferrin is a mammalian glycoprotein that chelates extracellular iron on mucosal surfaces, including the surface of the large intestine, where E. histolytica initiates infection. This work examined the interaction in vitro of E. histolytica trophozoites with human hololactoferrin (iron-saturated lactoferrin). A minimum concentration of 50 mM Fe from hololactoferrin su… Show more

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Cited by 44 publications
(36 citation statements)
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“…This result is in agreement with the observation that TF internalization is unsaturable [Welter et al, 2006]. The presence of clathrin has been demonstrated in some protozoa and in E. histolytica [León-Sicairos et al, 2005;López-Soto et al, 2009a;Reyes-López et al, 2011]; clathrin may be important in parasites for the acquisition of nutrients. The gene encoding the clathrin protein has been identified in the E. histolytica genome [Loftus et al, 2005].…”
Section: E Histolytica Transferrin Binding Proteins Ehtfbpssupporting
confidence: 81%
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“…This result is in agreement with the observation that TF internalization is unsaturable [Welter et al, 2006]. The presence of clathrin has been demonstrated in some protozoa and in E. histolytica [León-Sicairos et al, 2005;López-Soto et al, 2009a;Reyes-López et al, 2011]; clathrin may be important in parasites for the acquisition of nutrients. The gene encoding the clathrin protein has been identified in the E. histolytica genome [Loftus et al, 2005].…”
Section: E Histolytica Transferrin Binding Proteins Ehtfbpssupporting
confidence: 81%
“…Several studies have shown responses of the parasite to the absence or excess of iron and to the presence of iron-containing proteins [Serrano-Luna et al, 1998;Reyes-López et al, 2001;León-Sicairos et al, 2005;López-Soto et al, 2009a]. The concerted use of strategies to bind and use iron from different sources provides the parasite with the ability to use various host proteins for its benefit.…”
Section: Iron and E Histolyticamentioning
confidence: 99%
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“…25 This idea is reinforced by results we obtained in which apo-lactoferrin added to the BI-S-33 medium changed its saturation state to hololactoferrin, which was used by amoebas as an iron source. 26 In addition, iron has been implied in the pathogen's resistance to certain compounds. 25,[27][28][29] Figure 2.…”
Section: Resultsmentioning
confidence: 99%
“…Similarly, both holo-and apo-lactoferrin can bind to and kill Entamoeba histolytica trophozoites [22,23]. There are no investigations of the effect of lactoferrin on cryptosporidium or cyclospora.…”
Section: Effect Of Lactoferrin On Enteric Parasitesmentioning
confidence: 99%