Human Growth Hormone Release During Sleep: Electroencephalographic Correlation<sup>1</sup>

Parker, Donal C.; Sassin, Jon F.; Mace, John; Gotlin, Ronald W.; Rossman, Lawrence G.

doi:10.1210/jcem-29-6-871

Cited by 187 publications

(65 citation statements)

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“…As shown in Table III Hours after sleep onset dine was infused from 7:00 to 10:00 p.m. (study II), the percentage of time spent in SWS and REM sleep was comparable to that on the night when cyproheptadine was infused after the onset of sleep. DISCUSSION It is well-known that plasma GH increases during the early phase of sleep with a peak occurring within the first 90 min of sleep (16)(17)(18)(19). The lack of correlation between nocturnal GH release and plasma glucose, FFA, or insulin levels suggests that sleep-related GH release is not controlled by systemic metabolic substrates but by central nervous system rhythm (16,20).…”

Section: Resultsmentioning

confidence: 98%

“…The sleep-related GH release is known to be closely related to SWS under normal circumstances (16)(17)(18)(19). The apparent dissociation between the GH rise and SWS after the administration of cyproheptadine suggests that the subcortical mechanisms originating in the brain stem may act independently on cortical and hypothalamic areas under certain circumstances.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Suppression by cyproheptadine of human growth hormone and cortisol secretion during sleep.

Chihara¹,

Kato²,

Maeda³

et al. 1976

J. Clin. Invest.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Suppression by cyproheptadine of human growth hormone and cortisol secretion during sleep.

Chihara¹,

Kato²,

Maeda³

et al. 1976

J. Clin. Invest.

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“…GH secretion is enhanced during the 90-120 min immediately following sleep onset in temporal association with periods of slow-wave sleep (1)(2)(3). As much as 'Abbreviatiotns used in this paper: ANOVA, analysis of vari-ance; GH, growth hormone; ITT, insulin tolerance test; PRL, prolactin; REM, rapid-eye-movement.…”

Section: Introductionmentioning

confidence: 99%

Methscopolamine Inhibition of Sleep-Related Growth Hormone Secretion

Mendelson¹,

Sitaram²,

Wyatt³

et al. 1978

J. Clin. Invest.

108

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A B S T R A C T We have examined the effects of' cholinergic blockade with 0.5 mg methscopolamine bromide, intramuscularly, on sleep-related and insulininduced growth hormone (GH) secretion. 17 normal young men were studied; 8 had sleep studies, and 12 (including 3 who also had sleep studies) had insulin tolerance tests (ITT) with 0.1 U/kg of regular insulin. After an adjustment night in the sleep laboratory, saline control night and methscopolamine night studies were done in random se(luence; study procedures in-(cluded electroencephalographic, electromyographic, and electrooculographic recordings, and blood sampling every 20 min for hormone radioimmunoassays. Prolactin levels were also measured during sleep. For methscopolamine night studies, the mean overall control GH level of 2.89+0.44 ng/ml and the mean peak control GH level of' 11.09±3.11 ng/ml were dramatically reduced to 0.75±0.01 and 1.04+0.25 ng/ ml, respectively (P < 0.0001 and <0.001). Despite virtual absence of' GH secretion during the night in every study subject, no meas.ured sleep characteristic was affected by methscopolamine, including total slow-wave sleep ( methscopolamine had only a marginial effect oIn the GH response to insulin hypoglycemiiia. None of nine time points diff'ered significantly, as was also the case with peak levels, mean inerements, and areas under the curves (P > 0.2). Analysis of' variance did, however, indicate that the lower GH concentrations achieved during ITT after methscopolamine (average 31.7% below control) were significantly different than control concentrations. We conclude that the burst of' GH secretion which normally occurs after sleep onset is primed by a cholinergic mechanism which does not influence slow-wave sleep. Cholinergic mechanisms do not appear to play an important role in sleeprelated prolactin secretion. The contrast between the complete suppression of sleep-related GH release and the relatively small inhibitory effect on ITTinduced GH secretion suggests that the neurotransmitter mechanisms, and presumably the pathways, which subserve sleep-related GH secretion in man may be different from those which mediate the GH response to pharmacologic stimuli such as insulin.

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“…For instance, sleep/wakedependant processes substantially affect growth hormone (GH) and prolactin (PRL) secretion since these hormones are primarily regulated by homeostatic processes. The major peak of GH secretion is normally observed around sleep onset [38][39][40][41][42][43][44] , even when the sleep episode is delayed 42,45) . Sleep exerts a strong stimulant effect on PRL secretion [46][47][48][49] , and peak PRL levels are observed during the later part of the sleep episode 47,50,51) .…”

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confidence: 99%

Light Treatment and Circadian Adaptation to Shift Work

Boivin

James

2005

Ind Health

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Work at unconventional hours can have both long and short term consequences. Shift workers are often required to perform their duties at times that are not favoured by the body's endogenous clock, or circadian pacemaker. A typical night shift worker, for example, may report reductions in alertness and performance during shifts, or significant difficulty attaining sleep of recuperative value in the day, all the while being more likely to develop health complications. The study of circadian physiology has significantly contributed to our current ability to aid the shift worker deal with atypical schedules. We discuss the usefulness of light treatment as a countermeasure for maladaptation to atypical work schedules.

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Human Growth Hormone Release During Sleep: Electroencephalographic Correlation¹

Cited by 187 publications

References 4 publications

Suppression by cyproheptadine of human growth hormone and cortisol secretion during sleep.

Suppression by cyproheptadine of human growth hormone and cortisol secretion during sleep.

Methscopolamine Inhibition of Sleep-Related Growth Hormone Secretion

Light Treatment and Circadian Adaptation to Shift Work

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Human Growth Hormone Release During Sleep: Electroencephalographic Correlation1

Cited by 187 publications

References 4 publications

Suppression by cyproheptadine of human growth hormone and cortisol secretion during sleep.

Suppression by cyproheptadine of human growth hormone and cortisol secretion during sleep.

Methscopolamine Inhibition of Sleep-Related Growth Hormone Secretion

Light Treatment and Circadian Adaptation to Shift Work

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Human Growth Hormone Release During Sleep: Electroencephalographic Correlation¹