2016
DOI: 10.18632/aging.101078
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Abstract: Centenarians not only enjoy an extraordinary aging, but also show a compression of morbidity. Using functional transcriptomic analysis of peripheral blood mononuclear cells (PMBC) we identified 1721 mRNAs differentially expressed by centenarians when compared with septuagenarians and young people. Sub-network analysis led us to identify Bcl - xL as an important gene up-regulated in centenarians. It is involved in the control of apoptosis, cellular damage protection and also in modulation of immune response, al… Show more

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Cited by 39 publications
(27 citation statements)
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References 44 publications
(51 reference statements)
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“…BCL-xL expression was up-regulated during megakaryocyte differentiation [71], and subsequently, senescence was drastically reduced. We also reported that both MEFs and primary cultured human lymphocytes, transduced with a plasmid encoding BCL-xL, downregulated INK/ARF senescent pathway markers, such as p16 INK4a , p14 Arf , p21 Cip , and senescence-associated β-galactosidase (SA-β-GAL) [72]. Taken together, these results suggest a negative correlation between BCL-xL expression and senescence.…”
Section: Bcl-xl Dual Role In Senescencementioning
confidence: 58%
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“…BCL-xL expression was up-regulated during megakaryocyte differentiation [71], and subsequently, senescence was drastically reduced. We also reported that both MEFs and primary cultured human lymphocytes, transduced with a plasmid encoding BCL-xL, downregulated INK/ARF senescent pathway markers, such as p16 INK4a , p14 Arf , p21 Cip , and senescence-associated β-galactosidase (SA-β-GAL) [72]. Taken together, these results suggest a negative correlation between BCL-xL expression and senescence.…”
Section: Bcl-xl Dual Role In Senescencementioning
confidence: 58%
“…We have studied centenarians, as an example of successful aging, and have found that they overexpress BCL-xL [72]. By performing functional transcriptomic analysis of peripheral blood mononuclear cells (PMBC), we compared the expression patterns of 28.869 human genes in centenarians, septuagenarians, and young people.…”
Section: Bcl-xl Role In Successful Agingmentioning
confidence: 99%
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“…High throughput gene expression may produce both random and systematic errors, arising from the steps in RNA or protein purification, library preparation and/or amplification, hybridization, sequencing, mass spectrometry, reading arrays, and mapping and annotation of the reads 29,[39][40][41][42] It is generally hard to identify the types of errors and to find out which kind of experimental protocol provides more reliable data. While the measured concentration of each individual gene product may be in error, we show in this report that combining sufficient numbers of these concentrations into a pathway-oriented framework apparently generates significantly more stable data.…”
Section: Discussionmentioning
confidence: 99%
“…Nuestros resultados parecen estar en consonancia con recientes estudios que demuestran que el perfil transcriptómico en personas centenarias es similar al de personas jóvenes mientras que septuagenarios u octogenarios muestran un perfil más diferente con los otros dos grupos de edad 12,13 . Queda por aclarar si esta diferencia se debe a que los organismos más longevos presentan un perfil de expresión génica más parecido al de organismos más jóvenes o si se debe a una respuesta biológica que tiende a modificar la expresión génica para mantener los sistemas de supervivencia más adecuados.…”
Section: Discussionunclassified