Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease.

Sacchi, Nicoletta; Nalbantoglu, Joséphine; Sergovich, F. R.; Papas, Takis S.

doi:10.1073/pnas.85.20.7675

Cited by 16 publications

(6 citation statements)

References 40 publications

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“…The ETS2 gene is translocated from chromosome 21 to chromosome 8 in the specific translocation t(8;21) known to be associated with acute myelogenous leukemia (8,9). The location of the ETS2 gene at 21q22 has suggested that it may be a contributing genetic element in the cluster of genes whose amplification is associated with Down syndrome (DS) (9,10), and this concept is supported by the observation that the ETS2 gene is found in three copies in partial trisomies 21 associated with the DS phenotype (11,12).…”

supporting

confidence: 49%

c-ets-2 protooncogene has mitogenic and oncogenic activity.

Seth

Watson

Blair

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

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supporting

confidence: 49%

c-ets-2 protooncogene has mitogenic and oncogenic activity.

Seth

Watson

Blair

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

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“…etsl is amplified in a myelodisplastic syndrome (Ohyashiki et al, 1990). Extra dosage of ets2 may increase susceptibility to leukemia in Down's syndrome (Sacchi et al, 1988). The Ets2 mRNA level increases in an acute nonlymphoblastic leukemia (Santoro et al, 1992).…”

Section: Transformation By Ets Family Members Vets Induces Erythroblamentioning

confidence: 99%

The Ets family of transcription factors

Wasylyk

Hahn

Giovane

1993

European Journal of Biochemistry

790

485

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Interest in the Ets proteins has grown enormously over the last decade. The v‐ets oncogene was originally discovered as part of a fusion protein expressed by a transforming retrovirus (avian E26), and later shown to be transduced from a ceilular gene. About 30 related proteins have now been found in species ranging from flies to humans, that resemble the vEts protein in the so‐called ‘ets domain’. The ets domain has been shown to be a DNA‐binding domain, that specifically interacts with sequences containing the common core trinucleotide GGA. Furthermore, it is involved in protein–protein interactions with co‐factors that help determine its biological activity. Many of the Ets‐related proteins have been shown to be transcription activators, like other nuclear oncoproteins and anti‐oncoproteins (Jun, Fos, Myb, Myc, Rel, p53, etc.). However, Ets‐like proteins may have other functions, such as in DNA replication and a general role in transcription activation. Ets proteins have been implicated in regulation of gene expression during a variety of biological processes, including growth control, transformation, T‐cell activation, and developmental programs in many organisms. Signals regulating cell growth are transmitted from outside the cell to the nucleus by growth factors and their receptors, G‐proteins, kinases and transcription factors. We will discuss how several Ets‐related proteins fit into this scheme, and how their activity is regulated both post‐and pre‐translationally. Loss of normal control is often associated with conversion to an onco‐protein. vEts has been shown to have different properties from its progenitor, which might explain how it has become oncogenic. Oncogene‐related products have been implicated in the control of various developmental processes. Evidence is accumulating for a role for Ets family members in Drosophila development, Xenopus oocyte maturation, lymphocyte differentiation, and viral infectious cycles. An ultimate hope in studying transformation by oncoproteins is to understand how cells become cancerous in humans, which would lead to more effective treatments. vEts induces erythroblastosis in chicken. Cellular Ets‐family proteins can be activated by proviral insertion in mice and, most interestingly, by chromosome translocation in humans. We are at the beginning of understanding the multiple facets of regulation of Ets activity. Future work on the Ets family promises to provide important insights into both normal control of growth and differentiation, and deregulation in illness.

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“…The (59). Although no direct evidence links altered CD11/ CD18 expression to leukemogenesis per se, a large body of data suggests that cell-cell and cell-matrix interactions (some mediated by P2 integrins) are important in regulating differentiation and maturation of hematopoietic cells (52).…”

mentioning

confidence: 99%

The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements.

et al. 1994

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To define the minimal promoter responsible for expression of CD18 in myeloid and lymphoid cells, we generated 5' and 3' deletion constructs of a segment extending 785 bp upstream and 19 bp downstream of a major transcription start site and determined their effects on driving expression of the luciferase reporter gene in transfected hematopoietic cell lines. A region extending from nucleotides (nt) -302 to + 19 was sufficient for cell-restricted and phorbol ester-inducible expression. DNase I footprinting of this region revealed two adjacent protected segments extending from nt -81 to -68 (box A) and -55 to -41 (box B). When a construct of 47 nt in length containing box A and box B and lacking other 3' or 5' elements was cloned into a promoterless vector, it conferred tissue-specific and phorbol ester-inducible expression. Gel retardation revealed that the protein components of two major protein-DNA complexes that form on both box A and box B and are required for transcriptional activation are members of the Ets oncoprotein family; one is related to the GA-binding protein (GABP), and the other is related to PU.l/Spi-l. The minimal CD18 promoter, lacking TATA, CAAT, and initiator elements and consisting primarily of Ets repeats, may exemplify an emerging class of promoters with which the concerted binding of Ets factors is necessary and sufficient to mediate transcriptional activation through direct recruitment of the basal transcription machinery.

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Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease.

Cited by 16 publications

References 40 publications

c-ets-2 protooncogene has mitogenic and oncogenic activity.

c-ets-2 protooncogene has mitogenic and oncogenic activity.

The Ets family of transcription factors

The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements.

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