Human disease in ribeira valley, brazil caused by caraparu, a group c arbovirus - Report of a case

Iversson, Lygia Busch; Rosa, A.P.A. Travassos da; Coimbra, Terezinha Lisieux Moraes; Ferreira, Ivani B.; Nassar, E.S.

doi:10.1590/s0036-46651987000200009

Cited by 10 publications

(6 citation statements)

References 16 publications

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“…In the early 1970s, neutralizing antibodies for NEPUV were detected in bats from Trinidad, and the virus has been involved in human disease in Central America [ 28 ],[ 29 ]. CARV is the most widely distributed group C virus in the Amazon Basin and it causes human disease in southeast Brazil [ 30 ]. Group C arboviruses produce a febrile syndrome with sudden onset, including high fever, headache, chills, myalgia, photophobia and retrobulbar pain [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Neutralizing antibodies for orthobunyaviruses in Pantanal, Brazil

et al. 2017

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The Pantanal is a hotspot for arbovirus studies in South America. Various medically important flaviviruses and alphaviruses have been reported in domestic and wild animals in the region. To expand the knowledge of local arbovirus circulation, a serosurvey for 14 Brazilian orthobunyaviruses was conducted with equines, sheep and free-ranging caimans. Sera were tested for specific viral antibodies using plaque-reduction neutralization test (PRNT). Monotypic reactions were detected for Maguari, Xingu, Apeu, Guaroa, Murutucu, Oriboca, Oropouche and Nepuyo viruses. Despite the low titers for most of the orthobunyaviruses tested, the detection of monotypic reactions for eight orthobunyaviruses suggests the Pantanal as a region of great orthobunyavirus diversity. The present data, in conjunction with previous studies that detected a high diversity of other arboviruses, ratify the Pantanal as an important natural reservoir for sylvatic and medically important arboviruses in Brazil.

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Section: Discussionmentioning

confidence: 99%

Neutralizing antibodies for orthobunyaviruses in Pantanal, Brazil

et al. 2017

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“…Members of the California serogroup, including La Crosse, California encephalitis, Inkoo, and Tahyna viruses, are known to cause disease in humans [ 4 – 8 ]. Similarly, members of the Bunyamwera serogroup, including Cache Valley and Bunyamwera viruses [ 9 , 10 ], Simbu serogroup, including Akabane, Iquitos, and Schmallenberg viruses [ 11 – 13 ], and Group C, including Caraparu, Itaya, Marituba, and Oriboca viruses [ 14 – 16 ], are known to cause disease in humans or domestic animals. Because infection with Group C viruses results in a non-differentiated febrile (dengue-like) illness and the lack of available diagnostic assays for these viruses, it has been difficult to associate these viruses with human disease.…”

Section: Introductionmentioning

confidence: 99%

Identification and Genomic Analysis of a Novel Group C Orthobunyavirus Isolated from a Mosquito Captured near Iquitos, Peru

Treangen¹,

Schoeler

Phillippy³

et al. 2016

PLoS Negl Trop Dis

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Group C orthobunyaviruses are single-stranded RNA viruses found in both South and North America. Until very recently, and despite their status as important vector-borne human pathogens, no Group C whole genome sequences containing all three segments were available in public databases. Here we report a Group C orthobunyavirus, named El Huayo virus, isolated from a pool of Culex portesi mosquitoes captured near Iquitos, Peru. Although initial metagenomic analysis yielded only a handful of reads belonging to the genus Orthobunyavirus, single contig assemblies were generated for L, M, and S segments totaling over 200,000 reads (~0.5% of sample). Given the moderately high viremia in hamsters (>107 plaque-forming units/ml) and the propensity for Cx. portesi to feed on rodents, it is possible that El Huayo virus is maintained in nature in a Culex portesi/rodent cycle. El Huayo virus was found to be most similar to Peruvian Caraparu virus isolates and constitutes a novel subclade within Group C.

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“…CARV is known to be an etiological agent of human disease [1,7,8]. However, the complete biological and genetic features of this virus remain unknown.…”

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confidence: 99%

Caraparu virus (group C Orthobunyavirus): sequencing and phylogenetic analysis based on the conserved region 3 of the RNA polymerase gene

et al. 2007

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Here, for the first time, we report the nucleotide sequence of Caraparu virus (CARV) L segment and the analysis of the RNA polymerase region 3 encoded by this segment. The 1,404 bp nucleotide sequence shares the highest identity with Bunyamwera, La Crosse, Oropouche, and Akabane virus sequences. The amino acid sequence was deduced and aligned with sequences from members of the Bunyaviridae family and used for phylogenetic analysis. The CARV clustered in the Orthobunyavirus genus. The premotif A and motifs A-E are present in the region 3 of the Bunyaviridae family, were also conserved in CARV L protein, as well as other conserved regions among Orthobunyavirus genus.

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Human disease in ribeira valley, brazil caused by caraparu, a group c arbovirus - Report of a case

Cited by 10 publications

References 16 publications

Neutralizing antibodies for orthobunyaviruses in Pantanal, Brazil

Neutralizing antibodies for orthobunyaviruses in Pantanal, Brazil

Identification and Genomic Analysis of a Novel Group C Orthobunyavirus Isolated from a Mosquito Captured near Iquitos, Peru

Caraparu virus (group C Orthobunyavirus): sequencing and phylogenetic analysis based on the conserved region 3 of the RNA polymerase gene

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