Human Corneal Thickness and Its Impact on Intraocular Pressure Measures

Doughty, Michael J.; Zaman, Mohammed L.

doi:10.1016/s0039-6257(00)00110-7

Cited by 1,252 publications

(1,050 citation statements)

References 343 publications

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“…20, 27 Our models show some evidence of lower CCT being associated with increased age (p=0.06 in our main model and 0.02 in the model that includes an interaction between group and edema), consistent with the ambiguity in the literature. Also, since our population was predominantly older with an average age of 66 years, it is difficult to draw conclusions about age and CCT that could be generalized to a broader population.…”

Section: Commentsupporting

confidence: 86%

“…20 The lack of a significant difference in mean CCT between explicitly recruited controls with normal corneas by slit lamp biomicroscopy and unaffected family members collected during familial recruitment is reassuring. Interestingly, affected family members had on average thinner corneas at a given FECD grade than the index cases despite identical grading criteria for both groups.…”

Section: Commentmentioning

confidence: 99%

“…Within the general population, there is a normal variation of corneal thickness 20 and it is upon this variability that the effects of FECD are superimposed. Our study did not follow subjects longitudinally, since the primary objective of the study was to assess the genetic factors associated with advanced late onset FECD; thus, the change in CCT over time with advancing FECD and genetic factors associated with this phenotype by individual, as studied in several late-onset FECD families, 28, 29 was not examined.…”

Section: Commentmentioning

confidence: 99%

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Relationship of Fuchs Endothelial Corneal Dystrophy Severity to Central Corneal Thickness

et al. 2012

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Section: Commentsupporting

confidence: 86%

Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

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Relationship of Fuchs Endothelial Corneal Dystrophy Severity to Central Corneal Thickness

et al. 2012

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“…Both data points are comparable to measurements (mean 0.434) reported in the literature. 36 A weak correlation between corneal thickness and corneal power (r-value 0.6) was identified. Watters and Owens 37 have suggested a pachymetry threshold of 480 microns as a key diagnostic descriptor of keratoconus.…”

Section: Discussionmentioning

confidence: 94%

The Dundee University Scottish Keratoconus study: demographics, corneal signs, associated diseases, and eye rubbing

Weed

MacEwen

Giles

et al. 2007

Eye

228

164

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Aim To investigate and correlate the corneal, refractive, topographic and familial characteristics of a large cohort with keratoconus. Methods Prospective observational study of 200 consecutive patients presenting with keratoconus during the 4 year-period 1997-2000. Subjects were examined at enrolment and at a final review. Data were collected on demographic characteristics, referral route, symptoms, refractive correction, eye rubbing, family history, medical history, slit-lamp biomicroscopic corneal signs, and computerized corneal topography. Results Mean age at enrolment was 30.9710.4 (range, 12.2-72) years (N ¼ 200, 62.5% male, 93% white Caucasian) with a 5% family history of keratoconus. Atopic diseases included asthma (23%), eczema (14%), and hay fever (30%). Only 9% wore contact lenses before referral. Mean follow-up was 1004 days 7282 (range, 390-1335) and 9.778.9 (range, 1.1-60) years from diagnosis. The mean simulated K1 corneal power at enrolment was 51.7475.36 (range, 42.59-67.32) D and 88.5% exhibited bilateral keratoconus. Fifty-three (15%) topographically confirmed cones exhibited no clinical corneal signs at presentation. At enrollment, 56% had a pachymetry o0.480 mm increasing to 77% at final review. Forty-eight percent of subjects reported significant eye rubbing and there was a highly statistically significant difference (two sample t-test P ¼ 0.018) between keratoconus and control groups. TMS-2 axial corneal power was strongly associated with corneal scarring and age at diagnosis. The size of the scarring effect was 2.2 D (95% confidence interval (CI) 1.34, 3.06). Conclusions This study provides an overview of a large population with keratoconus highlighting presenting features and clinical and topographic progression over a 4 year-period.

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“…[6][7][8] To estimate the true intraocular hydrostatic pressure from the GAT readings, several investigators have proposed some formulae, which we employed for the purposes of this study, that take CCT into account. 6,7,[9][10][11] If applying these correction formulae to the Ocular Hypertension Treatment Study cohort, the proportion of subjects with a baseline IOPr21 mmHg in the randomly chosen eye at entry would be 52%, which would be only 10% if uncorrected by these formulae. 4 The noncontact tonometer (NCT) is now widely used as a screening tool for glaucoma because corneal anaesthesia and direct corneal contact are not required to obtain a reading.…”

Section: Introductionmentioning

confidence: 99%

Varying Effects of Corneal Thickness on Intraocular Pressure Measurements with Different Tonometers

Liu

Hsu

2004

Eye

109

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Aims To compare the intraocular pressure (IOP) measurements using the Goldmann applanation tonometer (GAT), noncontact tonometer (NCT), and ocular blood flow tonometer (OBFT), and to evaluate the effects of varying central corneal thickness (CCT) on the readings. Methods Ultrasound pachymetry and tonometry were performed on 170 eyes. Using the corrected GAT values that took CCT into account as the standard, we calculated the NCT and OBFT measurement errors related to the CCT variable by a linear regression model. Group comparisons were performed with the v 2 test and one-way ANOVA test. The correlation between the various tonometer measurements was analysed by Pearson's correlation method. Results Both the NCT (r ¼ 0.872, Po0.001) and OBFT measurements (r ¼ 0.861, Po0.001) were highly correlated with the GAT measurements. IOP measurements using the three tonometers were all correlated with CCT (all Po0.001), with the NCT measurements showing the greatest regression coefficient (b ¼ 0.063, r ¼ 0.650) and the GAT measurements the least (b ¼ 0.037, r ¼ 0.496). A linear regression model indicated that a 10 lm change in CCT resulted in a NCT measurement deviation of 0.47-0.98 mmHg and an OBFT measurement deviation of 0.29-0.81 mmHg.Conclusion Pressure readings with the GAT, NCT, and OBFT are all affected by CCT, with the NCT being the one most affected and the GAT the least. Our findings suggest CCT an essential variable to consider in interpreting IOP readings, especially for the NCT measurements.

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Human Corneal Thickness and Its Impact on Intraocular Pressure Measures

Cited by 1,252 publications

References 343 publications

Relationship of Fuchs Endothelial Corneal Dystrophy Severity to Central Corneal Thickness

Relationship of Fuchs Endothelial Corneal Dystrophy Severity to Central Corneal Thickness

The Dundee University Scottish Keratoconus study: demographics, corneal signs, associated diseases, and eye rubbing

Varying Effects of Corneal Thickness on Intraocular Pressure Measurements with Different Tonometers

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