2003
DOI: 10.1074/jbc.m303164200 View full text |Buy / Rent full text
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Abstract: The human combinatorial antibody library Fab 1 (Hu-CAL®-Fab 1) was generated by transferring the heavy and light chain variable regions from the previously constructed single-chain Fv library (Knappik, A., Ge, L., Honegger, A., Pack, P., Fischer, M., Wellnhofer, G., Hoess, A., Wö lle, J., Plü ckthun, A., and Virnekä s, B. (2000) J. Mol. Biol. 296, 57-86), diversified in both complementarity-determining regions 3 into a novel Fab display vector, yielding 2.1 ؋ 10 10 different antibody fragments. The modularity … Show more

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