Human Colonic Electrical Control Activity (EGA)

Sarna, Sushil K.; Bardakjian, Berj L.; Waterfall, W. E.; Lind, James

doi:10.1016/s0016-5085(19)30512-8

Cited by 104 publications

(36 citation statements)

References 24 publications

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“…27 28 In the colon however the ICC of the SMB region appear to produce the slow wave. 29 The present demonstration of a distinct SMB ICC network throughout the human colon is consistent with this functional 30 and that the myenteric plexus ICC is denser in the transverse colon. 23 In this study, we were unable to demonstrate an anatomical correlation with this functional observation as both the MPR and SMB ICC volume appeared to be relatively uniform throughout the colon, including the caecum.…”

Section: Discussionsupporting

confidence: 86%

Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation

Lyford

2002

Gut

248

181

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Background: Interstitial cells of Cajal (ICC) are required for normal intestinal motility. ICC are found throughout the human colon and are decreased in the sigmoid colon of patients with slow transit constipation. Aims: The aims of this study were to determine the normal distribution of ICC within the human colon and to determine if ICC are decreased throughout the colon in slow transit constipation. Patients: The caecum, ascending, transverse, and sigmoid colons from six patients with slow transit constipation and colonic tissue from patients with resected colon cancer were used for this study. Methods: ICC cells were identified with a polyclonal antibody to c-Kit, serial 0.5 µm sections were obtained by confocal microscopy, and three dimensional software was employed to reconstruct the entire thickness of the colonic muscularis propria and submucosa. Results: ICC were located within both the longitudinal and circular muscle layers. Two networks of ICC were identified, one in the myenteric plexus region and another, less defined network, in the submucosal border. Caecum, ascending colon, transverse colon, and sigmoid colon displayed similar ICC volumes. ICC volume was significantly lower in the slow transit constipation patients across all colonic regions. Conclusions: The data suggest that ICC distribution is relatively uniform throughout the human colon and that decreased ICC volume is pan-colonic in idiopathic slow transit constipation.

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Section: Discussionsupporting

confidence: 86%

Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation

Lyford

2002

Gut

248

181

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Section: Discussionmentioning

confidence: 99%

“…Spectral analysis reveals a wide range of spectral components; for example, less than 1 cpm mass propulsion or mass movement for defecation, 8 around 3-5 cpm, [8][9][10][11] and around 8-10 cpm. [8][9][10][11][12] Abdominal surface recordings of EGGs have shown that two spectral components, 2.5-3.5 cpm and 3.6-7.5 cpm, reflect colonic activities. 7,9,13,14 We obtained evidence that two similar spectral components in EGGs, of the 3-cpm group (2.5-4.9 cpm) and the 6-cpm group (5.0-7.4 cpm), reflected colonic activity, especially in an infraumbilical recording of 27 channel EGGs.…”

Section: Discussionmentioning

confidence: 99%

Topographical Electrogastrograms After Radical Esophagectomy with Colonic Replacement

et al. 2003

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“…4 The strongest frequency component in the total colonic electrical control activity frequency range of 2.0-13.0 c/min was first identified. Additional frequency components were considered to be present if their peaks were at least 25% in strength of the largest peak.…”

Section: Methodsmentioning

confidence: 99%

Electrical and contractile activities of the human rectosigmoid.

Sarna¹,

Latimer²,

Campbell³

et al. 1982

Gut

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The smooth muscle layers of the stomach and the small intestine show two types of electrical activities, the electrical control activity and the electrical response activity.' The electrical control activity controls the appearance, in time and space, of electrical response activity, when the latter is present. The electrical response activity occurs only on a part of the control wave cycle -that is, during the depolarised phase -and is directly associated with rhythmic or phasic contractions.Our postoperative colonic serosal recordings from

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Human Colonic Electrical Control Activity (EGA)

Cited by 104 publications

References 24 publications

Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation

Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation

Topographical Electrogastrograms After Radical Esophagectomy with Colonic Replacement

Electrical and contractile activities of the human rectosigmoid.

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