volume 66, issue 7, P4617-4621 1992
DOI: 10.1128/jvi.66.7.4617-4621.1992
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A Alonso, D Derse, B M Peterlin

Abstract: Levels of trans activation of the human immunodeficiency virus type 1 long terminal repeat (HIV-1 LTR) by the virally encoded transactivator Tat show marked species-specific differences. For example, levels of transactivation observed in Chinese hamster ovary (CHO) rodent cells are 10-fold lower than those in human cells or in CHO cells that contain the human chromosome 12. Thus, the human chromosome 12 codes for a protein or proteins that are required for optimal Tat activity. Here, the function of these cell…

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