Human chorionic gonadotrophin for recurrent miscarriage

Abstract

There is not enough evidence to evaluate the use of human chorionic gonadotrophin during pregnancy in order to prevent miscarriage in women with a history of unexplained recurrent spontaneous miscarriage.

First trimester threatened miscarriage treatment with human chorionic gonadotrophins: a randomised controlled trial

“…Quenby and Farquharson 5 looked at women with history of both recurrent miscarriage and oligomenorrhoeic cycles and showed their risk of miscarriage decrease by treatment with hCG; however, the number of the patients in the study group was small and had a very specific clinical profile. A Cochrane review of use of hCG treatment for the prevention of recurrent miscarriage 10 concluded that there was insufficient evidence to support its use in routine clinical practice.…”

First trimester threatened miscarriage treatment with human chorionic gonadotrophins: a randomised controlled trial

“…Quenby and Farquharson 5 looked at women with history of both recurrent miscarriage and oligomenorrhoeic cycles and showed their risk of miscarriage decrease by treatment with hCG; however, the number of the patients in the study group was small and had a very specific clinical profile. A Cochrane review of use of hCG treatment for the prevention of recurrent miscarriage 10 concluded that there was insufficient evidence to support its use in routine clinical practice.…”

Recurrent Miscarriage: Diagnostic and Therapeutic Procedures. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry Number 015/050)

“…A Cochrane meta-analysis of these five studies found that the administration of hCG led to a significant reduction in the frequency of miscarriage. However, this positive effect was no longer statistically significant when the analysis was done without the two methodologically weaker studies (OR 0.74; 95% CI: 0.44 – 1.23) 153 . The studies did not include data on LBR.…”

Treatment Modalities in Recurrent Miscarriages without Diagnosis

“…The Cochrane collaboration performed a meta-analysis approximately 13 years ago which involved 4 trials and a total of 180 patients. 23 The results suggested that there was a significant reduction in pregnancy loss when hCG was administered. However, due to the inclusion of 2 weak studies, these results could be neither confirmed nor recommended.…”

First trimester threatened miscarriage treatment with human chorionic gonadotrophins: a randomised controlled trial

“…Quenby and Farquharson 5 looked at women with history of both recurrent miscarriage and oligomenorrhoeic cycles and showed their risk of miscarriage decrease by treatment with hCG; however, the number of the patients in the study group was small and had a very specific clinical profile. A Cochrane review of use of hCG treatment for the prevention of recurrent miscarriage 10 concluded that there was insufficient evidence to support its use in routine clinical practice.…”

Recurrent Miscarriage: Diagnostic and Therapeutic Procedures. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry Number 015/050)

“…A Cochrane meta-analysis of these five studies found that the administration of hCG led to a significant reduction in the frequency of miscarriage. However, this positive effect was no longer statistically significant when the analysis was done without the two methodologically weaker studies (OR 0.74; 95% CI: 0.44 – 1.23) 153 . The studies did not include data on LBR.…”

Treatment Modalities in Recurrent Miscarriages without Diagnosis

“…The Cochrane collaboration performed a meta-analysis approximately 13 years ago which involved 4 trials and a total of 180 patients. 23 The results suggested that there was a significant reduction in pregnancy loss when hCG was administered. However, due to the inclusion of 2 weak studies, these results could be neither confirmed nor recommended.…”

First trimester threatened miscarriage treatment with human chorionic gonadotrophins: a randomised controlled trial

“…Quenby and Farquharson 5 looked at women with history of both recurrent miscarriage and oligomenorrhoeic cycles and showed their risk of miscarriage decrease by treatment with hCG; however, the number of the patients in the study group was small and had a very specific clinical profile. A Cochrane review of use of hCG treatment for the prevention of recurrent miscarriage 10 concluded that there was insufficient evidence to support its use in routine clinical practice.…”

Recurrent Miscarriage: Diagnostic and Therapeutic Procedures. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry Number 015/050)

“…A Cochrane meta-analysis of these five studies found that the administration of hCG led to a significant reduction in the frequency of miscarriage. However, this positive effect was no longer statistically significant when the analysis was done without the two methodologically weaker studies (OR 0.74; 95% CI: 0.44 – 1.23) 153 . The studies did not include data on LBR.…”

Treatment Modalities in Recurrent Miscarriages without Diagnosis

“…The Cochrane collaboration performed a meta-analysis approximately 13 years ago which involved 4 trials and a total of 180 patients. 23 The results suggested that there was a significant reduction in pregnancy loss when hCG was administered. However, due to the inclusion of 2 weak studies, these results could be neither confirmed nor recommended.…”