PLoS ONE volume 9, issue 5, Pe98461 2014 DOI: 10.1371/journal.pone.0098461 View full text
Aino L. K. Liukko, Tuure T. Kinnunen, Marja A. Rytkönen-Nissinen, Anssi H. T. Kailaanmäki, Jukka T. Randell, Bernard Maillère, Tuomas I. Virtanen

Abstract: Lipocalin allergens form a notable group of proteins, as they contain most of the significant respiratory allergens from mammals. The basis for the allergenic capacity of allergens in the lipocalin family, that is, the development of T-helper type 2 immunity against them, is still unresolved. As immunogenicity has been proposed to be a decisive feature of allergens, the purpose of this work was to examine human CD4+ T cell responses to the major dog allergen Can f 1 and to compare them with those to its human …

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