Human brucellosis

Franco, María Pía; Mulder, Maximilian; Gilman, Robert H.; Smits, Henk L.

doi:10.1016/s1473-3099(07)70286-4

Cited by 906 publications

(928 citation statements)

References 134 publications

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“…bacteremia in patients presenting with arthralgia, fever, and having risk factor(s) brucellosis depends on a combination of information derived from clinical examination and laboratory parameters, such as CRP level, ESR, and WBC count. Brucellosis is routinely overlooked, misdiagnosed, or at best diagnosed incidentally; therefore, physicians must become aware of and consider brucellosis in their differential diagnosis of febrile diseases [19]. The present study investigated 36 brucellosis cases with different clinic profiles that were helpful in making a differential diagnosis of brucellosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and serum profile of inflammatory biomarkers in patients with brucellosis

Liu

Zhao

2017

J Infect Dev Ctries

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Introduction: Brucellosis is a zoonosis caused by Brucella, a highly infectious Gram-negative coccobacillus that has been isolated from a variety of mammals. Brucella melitensis is considered the most common cause of human brucellosis. The aim of this retrospective study was to evaluate the diagnostic value of serum parameters that relate to Brucella melitensis infection. Methodology: This investigation retrospectively analyzed the clinical laboratory tests and symptoms of brucellosis, which was confirmed by microbiological and serological methods. A total of 36 patients (31 males, 5 females; mean age 49.17 ± 13.56 years) admitted with brucellosis were included in the study over a three-year period between 2012 and 2015 in Peking University People's Hospital (PKUPH). Results: A statistically significant increase was observed in C-reactive protein and erythrocyte sedimentation rate in patients with low titers of serum antibody when compared with those with high titers. No difference was observed between the two groups with respect to the other serum parameters such as procalcitonin or white blood cell count. Two blood culture systems also yielded different results. Conclusions: In this study, we demonstrated that culture can be improved by using multiple blood culture systems to isolate Brucella melitensis. We also found the different role of inflammatory markers play during the process of brucellosis. The present study may be a helpful reference in the diagnosis of brucellosis.

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Section: Discussionmentioning

confidence: 99%

Clinical features and serum profile of inflammatory biomarkers in patients with brucellosis

Liu

Zhao

2017

J Infect Dev Ctries

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“…Brucellae can gain entry into the human host via inhalation, ingestion, contact with mucosa, or puncture wounds such as needle sticks [29]. This is followed by an incubation of 10–21 days (but as long as 12 months), a brief bacteremia, and localization to the mononuclear phagocyte system [30].…”

Section: Pathogenesis Clinical Presentation and Risk Factor In Humansmentioning

confidence: 99%

“…Untreated, infections can result in undulating fevers due to re-current bacteremic episodes which is followed by new foci of infection (spine, joins, nerve, etc.). Humans, typically, do not produce clinical abortions due to brucellosis infections, thus constituting a dead-end host [29]. Abortions are a primary driver of transmission in animal populations [9].…”

Section: Pathogenesis Clinical Presentation and Risk Factor In Humansmentioning

confidence: 99%

“…However, the burden of brucellosis infection is greatest in developing countries. Inconsistent infrastructure (animal health and pasteurization in particular) and lack of funding perpetuate the uncontrolled spread of disease [29]. In developed countries, like the U.S., great strides have been made since the initiation of and provision of funding for control and eradication efforts.…”

Section: Control Strategiesmentioning

confidence: 99%

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Comparisons of brucellosis between human and veterinary medicine

Hull

Schumaker

2018

Infection Ecology & Epidemiology

146

129

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Brucellosis is the world’s most widespread zoonosis, but also ranks as one of the seven most neglected diseases, according to the World Health Organization. Additionally, it is recognized as the world’s most common laboratory-acquired infection. There are a reported 500,000 incident cases of human brucellosis per year. However, true incidence is estimated to be 5,000,000 to 12,500,000 cases annually. Once diagnosed, focus is directed at treating individual patients with antibiotic regimes, yet overall neglecting the animal reservoir of disease. Countries with the highest incidence of human brucellosis are Syria (1,603.4 cases per 1,000,000 individuals), Mongolia (391.0), and Tajikistan (211.9). Surveillance on animal populations is lacking in many developed and developing countries. According to the World Animal Health Information Database, Mexico had the largest number of reported outbreaks, 5,514 in 2014. Mexico is followed by China (2,138), Greece (1,268), and Brazil (1,142). The majority of these outbreaks is Brucella abortus, the etiologic agent of bovine brucellosis. Brucellosis is an ancient disease that still plagues the world. There are still knowledge gaps and a need for better diagnostics and vaccines to make inroads towards control and eradication.

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“…However, small ruminant brucellosis remains a problem in some of these countries as well as in all developing countries. Basically, brucellosis is almost always present where small ruminants are kept Franco et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Bayesian estimation of true prevalence, sensitivity and specificity of indirect ELISA, Rose Bengal Test and Slow Agglutination Test for the diagnosis of brucellosis in sheep and goats in Bangladesh

Rahman¹,

Saegerman²,

Berkvens³

et al. 2013

Preventive Veterinary Medicine

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a b s t r a c tThe true prevalence of brucellosis and diagnostic test characteristics of three conditionally dependent serological tests were estimated using the Bayesian approach in goats and sheep populations of Bangladesh. Serum samples from a random selection of 636 goats and 1044 sheep were tested in parallel by indirect ELISA (iELISA), Rose Bengal Test (RBT) and Slow Agglutination Test (SAT). The true prevalence of brucellosis in goats and sheep were estimated as 1% (95% credibility interval (CrI): 0.7-1.8) and 1.2% (95% CrI: 0.6-2.2) respectively. The sensitivity of iELISA was 92.9% in goats and 92.0% in sheep with corresponding specificities of 96.5% and 99.5% respectively. The sensitivity and specificity estimates of RBT were 80.2% and 99.6% in goats and 82.8% and 98.3% in sheep. The sensitivity and specificity of SAT were 57.1% and 99.3% in goats and 72.0% and 98.6% in sheep. In this study, three conditionally dependent serological tests for the diagnosis of small ruminant brucellosis in Bangladesh were validated. Considerable conditional dependence between IELISA and RBT and between RBT and SAT was observed among sheep. The influence of the priors on the model fit and estimated parameter values was checked using sensitivity analysis. In multiple test validation, conditional dependence should not be ignored when the tests are in fact conditionally dependent.

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Human brucellosis

Cited by 906 publications

References 134 publications

Clinical features and serum profile of inflammatory biomarkers in patients with brucellosis

Clinical features and serum profile of inflammatory biomarkers in patients with brucellosis

Comparisons of brucellosis between human and veterinary medicine

Bayesian estimation of true prevalence, sensitivity and specificity of indirect ELISA, Rose Bengal Test and Slow Agglutination Test for the diagnosis of brucellosis in sheep and goats in Bangladesh

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