Human brain atlas: For high‐resolution functional and anatomical mapping

Roland, Per E.; Graufelds, C. J.; Wǎhlin, J.; Ingelman, L.; Andersson, Mats; Ledberg, Anders; Pedersen, J. R.; Åkerman, S.; Dabringhaus, Andreas; Zilles, Karl

doi:10.1002/hbm.460010303

Cited by 221 publications

(139 citation statements)

References 27 publications

(37 reference statements)

Supporting

Mentioning

138

Contrasting

Order By: Relevance

“…The mean location, its SD, and current orientation (blue dot, circle, and line, respectively) of the cuneus and inferior occipital sources are displayed in a standard brain (18). The red dot displays the mean location of left and right V1 from Hasnain et al (13), who reported, however, the average location of the upper and lower visual field representations.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Coinciding early activation of the human primary visual cortex and anteromedial cuneus

Vanni¹,

Tanskanen²,

Seppä³

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

200

127

View full text Add to dashboard Cite

Proper understanding of processes underlying visual perception requires information on the activation order of distinct brain areas. We measured dynamics of cortical signals with magnetoencephalography while human subjects viewed stimuli at four visual quadrants. The signals were analyzed with minimum current estimates at the individual and group level. Activation emerged 55-70 ms after stimulus onset both in the primary posterior visual areas and in the anteromedial part of the cuneus. Other cortical areas were active after this initial dual activation. Comparison of data between species suggests that the anteromedial cuneus either comprises a homologue of the monkey area V6 or is an area unique to humans. Our results show that visual stimuli activate two cortical areas right from the beginning of the cortical response. The anteromedial cuneus has the temporal position needed to interact with the primary visual cortex V1 and thereby to modify information transferred via V1 to extrastriate cortices.A natomy of connections between primate visual cortices suggests a hierarchical organization of signal processing (1). However, the order of processes at different functional areas cannot be directly deduced from the anatomical hierarchy without relevant timing information. In monkeys, several areas become active immediately after the primary visual cortex (V1), while another set of areas is active at clearly longer latencies (2, 3). The areas showing early responses, such as V5͞middle temporal area (MT), medial superior temporal area, and frontal eye field, are specialized in analyzing dynamical visual information and in visuomotor transformation (for reviews, see refs. 4 and 5). The areas with longer latencies, such as V4, are sensitive to object form and color and participate in object recognition (6, 7). The dissimilarities in activation latencies and functional properties of these areas suggest diversity in the type and amount of necessary input and preprocessing before activation. Given the differences between monkey and human visual cortices (for a review, see ref. 8), we aimed to explore the dynamics and distribution of early cortical activation in humans. Neuromagnetic signals were recorded while the subjects viewed pattern reversal or luminance stimuli at the four visual quadrants. The signals were analyzed with minimum current estimates (MCEs), which require minimal human intervention for determining the location and orientation of the cortical currents (9). The individual three-dimensional estimates were aligned with a nonlinear transformation according to individual brain shapes (10, 11), and both the individual and group average MCEs were compared with the existing maps of human visual cortices (12-16). Materials and MethodsSubjects and Stimuli. We studied five female and five male subjects (mean age 27 years, range 20-42 years). The stimuli were generated with a Macintosh computer and presented with a dataprojector (VistaPro, Electrohome Ltd., Ontario, Canada) on a back projection screen, with viewing d...

show abstract

Section: Resultsmentioning

confidence: 99%

“…Estimates of individual signals were calculated separately for each time point. For the group average, the individual estimates were aligned on a standard brain (18) and then averaged. The alignment phase applies first a 12-parameter affine transformation (11), followed by a refinement with an elastic nonlinear transformation (10).…”

Section: Methodsmentioning

confidence: 99%

Coinciding early activation of the human primary visual cortex and anteromedial cuneus

Vanni¹,

Tanskanen²,

Seppä³

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

200

127

View full text Add to dashboard Cite

show abstract

“…The bilateral caudate nuclei were manually delineated on the structural MRI scans for each individual using Human Brain Atlas software (Roland et al, 1994). The cerebellum, where DA D1 receptor density is negligible, was delineated on six central slices and served as reference region (Hall et al, 1988).…”

Section: Pet Datamentioning

confidence: 99%

Caudate Dopamine D1 Receptor Density Is Associated with Individual Differences in Frontoparietal Connectivity during Working Memory

Rieckmann¹,

Karlsson²,

Fischer³

et al. 2011

J. Neurosci.

View full text Add to dashboard Cite

We assess the relationship of age-related losses in striatal D1 receptor densities to age-related reductions in functional connectivity between spatially distinct cortical regions in healthy human participants. Previous neuroimaging studies have reported age-related differences in functional connectivity of the frontoparietal working memory network and the default mode network during task performance. We used functional magnetic resonance imaging and seed-based connectivity (right dorsolateral and medial prefrontal cortex) to extend these findings: Anterior-posterior connectivity of both these functional networks was reduced in older (65-75 years, n ϭ 18) compared with younger (20 -30 years, n ϭ 19) adults, whereas bilateral connectivity in prefrontal cortex was increased in older adults. Positron emission tomography with the D1 receptor ligand [ 11 C]SCH23390 was used to assess caudate D1 receptor density in the same sample. Older adults showed significantly reduced caudate D1 receptor density compared to the younger adults. Of key interest, partial correlations showed that individual differences in caudate D1 receptor density were positively associated with individual differences in dorsolateral prefrontal connectivity to right parietal cortex (BA40) and negatively with medial prefrontal connectivity to right parietal cortex (BA40 and postcentral gyrus), after controlling for age. We found no correlation of caudate D1 receptor density with anteriorposterior coupling within the default mode network or with bilateral frontal connectivity. These results are consistent with animal work that has identified a role for caudate D1 receptors in mediating information transfer between prefrontal areas and parietal cortex.

show abstract

“…Recently, methods have been developed to generate probabilistic atlases of cortical areas in a stereotaxic coordinate system by matching the intensities of volumetric brain images via linear transformations (Talairach and Tournoux, 1988) or nonlinear transformations (Roland et al, 1994;Schormann and Zilles, 1998). These volume-based intersubject registration techniques were used to build a probabilistic atlas of human primary visual cortex (V1) (Amunts et al, 2000), as well as a number of other cortical areas (Amunts et al, 1999;Geyer et al, 1999;Grefkes et al, 2001;Morosan et al, 2001;Rademacher et al, 2001b,a;Eickhoff et al, 2007;Amunts et al, 2005;Wilms et al, 2005;Caspers et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Accurate prediction of V1 location from cortical folds in a surface coordinate system

et al. 2008

View full text Add to dashboard Cite

Previous studies demonstrated substantial variability of the location of primary visual cortex (V1) in stereotaxic coordinates when linear volume-based registration is used to match volumetric image intensities (Amunts et al., 2000). However, other qualitative reports of V1 location (Smith, 1904;Stensaas et al., 1974;Rademacher et al., 1993) suggested a consistent relationship between V1 and the surrounding cortical folds. Here, the relationship between folds and the location of V1 is quantified using surface-based analysis to generate a probabilistic atlas of human V1. High-resolution (about 200 μm) magnetic resonance imaging (MRI) at 7 T of ex vivo human cerebral hemispheres allowed identification of the full area via the stria of Gennari: a myeloarchitectonic feature specific to V1. Separate, whole-brain scans were acquired using MRI at 1.5 T to allow segmentation and mesh reconstruction of the cortical gray matter. For each individual, V1 was manually identified in the high-resolution volume and projected onto the cortical surface. Surface-based intersubject registration (Fischl et al., 1999b) was performed to align the primary cortical folds of individual hemispheres to those of a reference template representing the average folding pattern. An atlas of V1 location was constructed by computing the probability of V1 inclusion for each cortical location in the template space. This probabilistic atlas of V1 exhibits low prediction error compared to previous V1 probabilistic atlases built in volumetric coordinates. The increased predictability observed under surface-based registration suggests that the location of V1 is more accurately predicted by the cortical folds than by the shape of the brain embedded in the volume of the skull. In addition, the high quality of this atlas provides direct evidence that surface-based intersubject registration methods are superior to volume-based methods at superimposing functional areas of cortex, and therefore are better suited to support multi-subject averaging for functional imaging experiments targeting the cerebral cortex.

show abstract

Human brain atlas: For high‐resolution functional and anatomical mapping

Cited by 221 publications

References 27 publications

Coinciding early activation of the human primary visual cortex and anteromedial cuneus

Coinciding early activation of the human primary visual cortex and anteromedial cuneus

Caudate Dopamine D1 Receptor Density Is Associated with Individual Differences in Frontoparietal Connectivity during Working Memory

Accurate prediction of V1 location from cortical folds in a surface coordinate system

Contact Info

Product

Resources

About