Human bocavirus in acute gastroenteritis in children in Brazil

Campos, Gúbio Soares; Sampaio, Madina Lyve Silva; Menezes, Aline Dórea Luz; Tigre, Dellane Martins; Moura-Costa, Lília Ferreira de; Chinalia, Fábio Alexandre; Sardi, Silvia Inês

doi:10.1002/jmv.24293

Cited by 26 publications

(33 citation statements)

References 22 publications

(35 reference statements)

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“…In this study, HBoV was detected in 13 fecal samples from patients with AGE (9.1%). The reported detection frequency rate is within the range reported in previous studies, which is from 0.9% to 41.9% (in most of the studies this frequency was less than 20%) [Chieochansin et al, ; Pham et al, ; Levican et al, ; Kim, ; Alam et al, ; Campos et al, ]. Among the 13 cases of HBoV, 12 were HBoV‐1, and one HBoV‐2.…”

Section: Discussionsupporting

confidence: 77%

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Human bocavirus in children with acute gastroenteritis in Albania

Rosa

Libera

Iaconelli

et al. 2015

Journal of Medical Virology

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Human Bocavirus (HBoV) has been recently identified in association with acute viral gastroenteritis (AGE). The objective of this work was to investigate the prevalence of HBoV in children with AGE in Albania. Stool specimens collected from 142 children were analyzed by amplification of partial NP1 and Vp1/Vp2 genes. HBoV was detected in 13 samples (9.1%), 12 HBoV-1 and one HBoV-2. All HBoV-positive patients were co-infected with rotavirus and/or adenovirus, a finding which might indicate that there is no clear causal association of this agent with diarrhea. Further investigation is needed to assess the pathogenic role of HBoV in childhood diarrhea.

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Section: Discussionsupporting

confidence: 77%

“…The prevalence of HBoV in fecal specimens from patients with gastroenteritis has been reported worldwide [Chieochansin et al, 2008;Pham et al, 2011;Levican et al, 2013;Kim, 2014;Alam et al, 2015;Campos et al, 2015] but so far epidemiological data from Albania is not available.…”

Section: Introductionmentioning

confidence: 99%

Human bocavirus in children with acute gastroenteritis in Albania

Rosa

Libera

Iaconelli

et al. 2015

Journal of Medical Virology

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“…However, no patient showed a positive result of HBoV in both NPSs and fecal specimens. This finding seems to be reasonable given that penetration of the virus from the respiratory tract to the gastrointestinal tract takes time [21, 25]. …”

Section: Discussionmentioning

confidence: 90%

“…Previous reports have indicated detection rates of HBoV in pediatric patients with respiratory tract infection symptoms ranging from 1.5% to 19% [9, 18, 19], and those in pediatric patients with gastroenteritis symptoms ranging from 0.8% to 42% [13, 20, 21]. Such high variation among studies may be due to differences in geography, season, and detection methods of HBoV.…”

Section: Discussionmentioning

confidence: 99%

“…However, HBoV-1 is also often detected in fecal specimens together with HBoV-2 [21], and in some regions, HBoV-1 was the most frequently detected HBoV genotype from fecal specimens [13, 24]. Although the etiology of gastroenteritis caused by HBoV-1 has not yet been clearly revealed, it has been speculated that HBoV first causes respiratory tract infections that persist without symptoms for several months; thereafter, the virus penetrates to the gastrointestinal tract and causes symptoms of gastroenteritis [21, 25]. In this study, only the HBoV-1 genotype was detected in both the NPSs and fecal specimens.…”

Section: Discussionmentioning

confidence: 99%

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Human Bocavirus in Korean Children with Gastroenteritis and Respiratory Tract Infections

Lee

Kim

et al. 2016

BioMed Research International

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Human bocaviruses (HBoVs) are suggested to be etiologic agents of childhood respiratory and gastrointestinal infections. There are four main recognized genotypes of HBoVs (HBoV1–4); the HBoV-1 genotype is considered to be the primary etiologic agent in respiratory infections, whereas the HBoV2–4 genotypes have been mainly associated with gastrointestinal infections. The aim of the present study was to determine the distribution of HBoV genotypes in children with respiratory or gastrointestinal infections in a hospital in Korea. A total of 662 nasopharyngeal swabs (NPSs) and 155 fecal specimens were collected from children aged 5 years or less. Polymerase chain reaction (PCR) was conducted to detect the NS1 HBoV gene. The VP1 gene of HBoV was further amplified in samples that were positive for the NS1 gene. The PCR products of VP1 gene amplification were genotyped by sequence analysis. HBoV was detected in 69 (14.5%) of 662 NPSs and in 10 (6.5%) of 155 fecal specimens. Thirty-three isolates from NPSs and five isolates from fecal specimens were genotyped, and all 38 sequenced isolates were identified as the HBoV-1 genotype. HBoV-1 is the most prevalent genotype in children with respiratory or gastrointestinal HBoV infections in a hospital in Korea.

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Prevalence, molecular characterization, and clinical features of human bocavirus in children under 5 years of age with acute gastroenteritis admitted to a specialized children's hospital in Iran: A cross‐sectional study

Kachooei,

Karbalaie Niya,

Khales

et al. 2023

Health Science Reports

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Background and AimsAlthough some reports have confirmed the role of human bocavirus (HBoV) in respiratory infections, the importance of this virus in causing acute gastroenteritis has not yet been proven. This study aimed to determine the molecular prevalence of HBoV in children under 5 years old with gastroenteritis and to compare the clinical symptoms of HBoV‐positive and ‐negative gastroenteritis cases.MethodsA total of 100 stool samples were collected from children with gastroenteritis hospitalized in a pediatric hospital in Tehran, Iran. Demographic and clinical data were collected from patients' medical records. Viral genomic DNA was extracted from stool samples and amplified using the PCR assay. Finally, sequencing was used to determine the genotype of HBoV.ResultsThe HBoV genome was detected in 14 samples (14%). The highest prevalence of HBoV was observed in the age range of 24–60 months (n = 5; 35.7%); However, no statistically significant relationship was observed between the prevalence of HBoV and age groups (p = 0.09). Nine (64.3%) and 5 (35.7%) HBoV‐positive cases were boys and girls, respectively (p = 0.45). Fever, vomiting, and heartache were seen in 5 (35.7%), 3 (21.4%), and 1 (7.1%) HBoV‐positive patients, respectively. Overall, no significant difference was observed in any of the investigated clinical manifestations between patients positive or negative for HBoV. Five HBoV‐positive samples were subjected to sequencing and all five sequenced samples were genotype 3.ConclusionHBoV infections can be considered a risk factor for causing at least a portion of acute gastroenteritis cases in children under 5 years of age.

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Human bocavirus in acute gastroenteritis in children in Brazil

Cited by 26 publications

References 22 publications

Human bocavirus in children with acute gastroenteritis in Albania

Human bocavirus in children with acute gastroenteritis in Albania

Human Bocavirus in Korean Children with Gastroenteritis and Respiratory Tract Infections

Prevalence, molecular characterization, and clinical features of human bocavirus in children under 5 years of age with acute gastroenteritis admitted to a specialized children's hospital in Iran: A cross‐sectional study

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