2010
DOI: 10.1128/jvi.02719-09
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Abstract: Human bocavirus (HBoV) was recently discovered and classified in the Bocavirus genus (family Parvoviridae, subfamily Parvovirinae) on the basis of genomic similarity to bovine parvovirus and canine minute virus. HBoV has been implicated in respiratory tract infections and gastroenteric disease in children worldwide, yet despite numerous epidemiological reports, there has been limited biochemical and molecular characterization of the virus. Reported here is the three-dimensional structure of recombinant HBoV ca… Show more

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Cited by 81 publications
(96 citation statements)
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References 64 publications
(69 reference statements)
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“…Similar to the BPV cryo-reconstructed map, ordered density was observed below the 5-fold axes in the HBoV1 cryo-reconstructed map (Fig. 5B), and 9 residues were built into this density (17). However, the interior end of the channel in HBoV1 appears to be morphologically different from that in BPV (Fig.…”
Section: Resultssupporting
confidence: 57%
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“…Similar to the BPV cryo-reconstructed map, ordered density was observed below the 5-fold axes in the HBoV1 cryo-reconstructed map (Fig. 5B), and 9 residues were built into this density (17). However, the interior end of the channel in HBoV1 appears to be morphologically different from that in BPV (Fig.…”
Section: Resultssupporting
confidence: 57%
“…Uniquely, the 2-fold axes have a flat surface flanked by a depression. A comparison to the previously reported HBoV1 structure, determined to a 7.9-Å resolution by cryo-reconstruction (17), revealed conserved density extending the 5-fold channel radially inwards in both viruses, while differences were located on the capsid surface. Surface loop differences, clustered at or close to 2-, 3-, and 5-fold axes in addition to the capsid surface region between the 2-and 5-fold axes (the 2/5-fold wall), gave each Bocaparvovirus capsid a distinctive surface topology.…”
mentioning
confidence: 63%
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“…In studies like these, the use of several chemical inhibitors having different modes of action help to somewhat mitigate the problem of cloudy interpretation if the results are mutually supportive. A recent report provided cryoelectron microscopic images of the HBoV particle (Gurda et al, 2010). Other reports show the small, T=1 capsid of parvoviruses displays amino acid side chains to the inner capsid surface which bond to the bases of the single stranded genome .…”
Section: Introductionmentioning
confidence: 99%