Human blood cholinesterase activity—Holland Marsh, Ontario, 1976

Brown, John Russell; Chai, F.; Chow, Linda; Stopps, G. J.

doi:10.1007/bf01685848

Cited by 11 publications

(5 citation statements)

References 2 publications

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“…This is in agreement with other reports [Trotter and Fairburn, 1966;Brown et al, 1978;Trevilla Guerrero, 1981]. A significant in crease in the enzyme activity was found only in newly born children [Lund Karlsen et al, 1981].…”

Section: Discussionsupporting

confidence: 82%

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Serum Cholinesterase Activity in Population Samples from Iraq

et al. 1984

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Serum cholinesterase activity has been determined from normal subjects in a sample of the Iraqi population. The enzyme activity was distributed over a comparatively wide range. There was a highly significant difference between males and females with respect to the enzyme level, although the values were relatively higher than those reported elsewhere. The enzyme activity showed no relationship with age and blod group in both sexes.

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Section: Discussionsupporting

confidence: 82%

“…1965;Levine et al, 1966]. However, some reports have claimed that no such correlation could be found [Trotter and Fairburn, 1966;Brown et al, 1978].…”

Section: Discussionmentioning

confidence: 99%

Serum Cholinesterase Activity in Population Samples from Iraq

et al. 1984

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“…But of all the complaints of possible ChE-related symptoms, a significantly lower AChE activity was observed only in those who reported sweating as compared to those who did not (P<0.05). 13) The levels of PChE were higher than the levels of AChE both in the OP exposed workers and controls. Such observations are not typical of this study and similar results were noted by Rider et al 14) and Brown et al 13) There is no correlation between AChE and PChE values in the absence of ChE inhibition and PChE is highly influenced by several factors among which sex, age, race and seasonal variation are some of the most important ones').…”

Section: Resultsmentioning

confidence: 90%

“…13) The levels of PChE were higher than the levels of AChE both in the OP exposed workers and controls. Such observations are not typical of this study and similar results were noted by Rider et al 14) and Brown et al 13) There is no correlation between AChE and PChE values in the absence of ChE inhibition and PChE is highly influenced by several factors among which sex, age, race and seasonal variation are some of the most important ones'). The high level of PChE both in the control and OP exposed workers may be due to the fact that all the study subjects were males.…”

Section: Resultsmentioning

confidence: 90%

Cholinesterase Status of Some Ethiopian State Farm Workers Exposed to Organophosphate Pesticides

Lakew¹,

Mekonnen

1998

Journal of Occupational Health

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Cholinesterase Status of Some Ethiopian State Farm Workers Exposed to Organophosphate Pesticides : Kibruyisfa Lakew, et al. Occupational Safety and Health Division, Region 14 Labour and Social Affairs Bureau—The effects of organophosphate (OP) pesticide exposure on cholinesterase (ChE) activities were assessed in relation to occupational factors by studying 430 pest control workers from three state farms and 161 comparable controls. Plasma cholinesterase (PChE) and erythrocyte cholinesterase (AChE) activities were determined by an electrometric method. Plasma alkaline phosphatase (AP) and glutamic pyruvic transaminase (GPT) were estimated colorimetrically by using diagnostic kits 6391 and 1442520 respectively. Information on OP poisoning symptoms and related occupational factors were collected based on the WHO recommendations. Pest control workers had significantly lower PChE and AChE activities than the controls (P<0.001). In addition, 58 (13.5%) and 47 (10.9%) of the exposed workers had PChE and AChE activities below the lower limits of the controls respectively. Normal plasma AP and GPT values without significant difference from the controls were noted. Among the exposed population, the “spray men” and those who were exposed for 5 years or less were found to be the most affected groups. Although poisoning symptoms were more frequent in the exposed workers than in the controls, only sweating was found to have an association with a significant reduction in AChE activities (P<0.05). The study revealed that the health risks are more apparent in the exposed workers and are of immediate concern. Pre‐placement and periodic medical examination and creation of swareness among the exposed population are recommended to minimize the problem.

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“…In addition, subjects may have low plasma ChE activity as the result of hepatic disease [11,12]. The decrease in plasma ChE might be transient, but in some patients it may be permanent, as after prolonged exposure to anticholinesterase agents, the inhibitor being covalently bound to the active site of the enzyme [13][14][15]. This is demonstrated in the following case report.…”

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confidence: 99%

Prolonged Suxamethonium-Induced Neuromuscular Blockade Associated With Organophosphate Poisoning

Pérez

Pretel

Royo

et al. 1988

British Journal of Anaesthesia

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We report a patient, exposed to Malathion during agricultural work, who suffered a prolonged apnoea after the administration of suxamethonium. He had a normal phenotype (E1u E1u), but an extremely low plasma cholinesterase activity. The diagnosis was made by assaying cholinesterase activity and analysing the enzymic components by electrophoresis on polyacrylamide gel slabs. The results indicated that the apnoea was a result of the low activity of plasma cholinesterase induced by Malathion.

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Human blood cholinesterase activity—Holland Marsh, Ontario, 1976

Cited by 11 publications

References 2 publications

Serum Cholinesterase Activity in Population Samples from Iraq

Serum Cholinesterase Activity in Population Samples from Iraq

Cholinesterase Status of Some Ethiopian State Farm Workers Exposed to Organophosphate Pesticides

Prolonged Suxamethonium-Induced Neuromuscular Blockade Associated With Organophosphate Poisoning

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