Human biomonitoring to evaluate exposure to toxic and essential trace elements during pregnancy. Part A. concentrations in maternal blood, urine and cord blood.

Bocca, Beatrice; Ruggieri, Flavia; Pino, Anna; Rovira, Joaquim; Calamandrei, Gemma; Martínez, María Ángeles; Domingo, José L.; Alimonti, Andrea; Schuhmacher, Marta

doi:10.1016/j.envres.2019.108599

Cited by 74 publications

(62 citation statements)

References 62 publications

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“…Main sources of heavy metals include contaminated food and drinking water, and tobacco smoking 9 . Metals absorbed in maternal blood stream can be then differentially transferred through the placenta to the fetus 10,11 …”

Section: Introductionmentioning

confidence: 99%

Foetal exposure to heavy metals and risk of atopic diseases in early childhood

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Calciano

et al. 2020

Pediatric Allergy Immunology

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Background Accumulating evidence suggests that in utero exposures can influence the development of the immune system and thus contribute to disease development. Studies investigating the association between prenatal exposures to heavy metals and atopic diseases, however, are scarce. Methods Children from the EDEN birth cohort were prospectively followed up using parental questionnaires with validated questions on asthma, allergic rhinitis, eczema, and food allergy symptoms. The questionnaires were administered every 4 months during the children's first year, and then every year until the age of 5, with a final survey at the age of 8. Serum concentrations of lead (Pb), cadmium (Cd), and manganese (Mn) were assessed in maternal blood samples collected during mid‐pregnancy and in cord blood of 651 mother‐children pairs. Hazard ratios (HR) for the incidence of each atopic disease in relation to the exposure to metals were calculated using Cox proportional hazard models. Results Levels of Cd in cord blood were associated with greater risk of asthma (hazard ratio [95% confidence interval] for upper vs lower quartile: 1.81 [1.00‐3.29]), eczema (1.60 [1.09‐2.35]), and food allergy (3.17 [1.36‐7.38]), while Mn levels in maternal serum were associated with eczema (1.55 [1.05‐2.28]). These associations were similar in males and females and were confirmed using log concentrations of metals as exposures. Conclusions Our results support the hypothesis that fetal exposure to heavy metals may affect the development of asthma, eczema, and food allergy in childhood and suggest that timing of exposure in utero may have a role in these associations.

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Section: Introductionmentioning

confidence: 99%

Foetal exposure to heavy metals and risk of atopic diseases in early childhood

Pesce

Sesé

Calciano

et al. 2020

Pediatric Allergy Immunology

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“…However, it is important to point out that B-Cd reflects Cd exposure over the previous 2-3 months, which could reduce the effect of the time lag between the blood and dietary data collections. In addition, both B-Cd and urine Cd are stable during pregnancy [66]. Dietary patterns in pregnancy have also been shown to be stable [67], as have intakes of energy and macronutrients [68][69][70].…”

Section: Discussionmentioning

confidence: 99%

Maternal Diet During Pregnancy and Blood Cadmium Concentrations in an Observational Cohort of British Women

et al. 2020

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Few studies have investigated the extent to which diet predicts body Cd concentrations among women of reproductive age, and pregnant women in particular. The aim of this study was to examine diet as a predictor of blood Cd concentrations in pregnant women participating in the UK Avon Longitudinal Study of Parents and Children (ALSPAC). Whole blood samples were analysed for Cd (median 0.26 (IQR 0.14–0.54) µg/L). Dietary pattern scores were derived from principal components analysis of data from a food frequency questionnaire. Associations between dietary pattern scores and foods/food groups with blood Cd ≥ median value were identified using adjusted logistic regression (n = 2169 complete cases). A health conscious dietary pattern was associated with a reduced likelihood of B-Cd ≥0.26 µg/l (OR 0.56 (95% CI 0.39–0.81)). There were similarly reduced likelihoods for all leafy green and green vegetables (0.72 (0.56–0.92) when consumed ≥4 times/week vs ≤1 to ≥3 times/week) and with all meats (0.66 (0.46–0.95) when consumed ≥4 times/week vs ≤ once in 2 weeks). Sensitivity analysis excluding smokers showed similar results. The evidence from this study provides continued support for a healthy and varied diet in pregnancy, incorporating foods from all food groups in accordance with national recommendations, without the need for specific guidance.

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“…One study observed that as the weeks of pregnancy progressed, the selenium concentration in the urine was reduced. Such a fact was considered because if the mother does ingest the ideal amount or is supplemented, in pregnancy as well as in breastfeeding, there is no guarantee that adequate transference via the placenta and mammary glands will occur [62].…”

Section: Seleniummentioning

confidence: 99%

“…In a study that evaluated concentrations of minerals in the blood, umbilical cord, and urine of pregnant women, copper and zinc showed much lower levels in the cord than in the blood, suggesting that transplacental passage is limited. Other effects included diminished levels from the first to the third trimester due to hemodilution, reduction of the levels of zinc-binding protein, and hormonal alterations [62].…”

Section: Zincmentioning

confidence: 99%

“…Iodine thyroid hormones [15,16] brain development [55] redox balance [20] relationship with selenium [21] neuronal development of children [19] mental retardation [17,58] fetal hypothyroidism [17,[19][20][21]56] delay in development [97] association with autism [98] association with attention deficit [98] association with hyperactivity disorder [98] drop in IQ points [2,55] results of alphabetization [99] Selenium antioxidant activity [21] action in the immune system [16,26] present in the thyroid gland [22] intolerance to glucose [29,[59][60][61] alterations in the lipidic profile [29,[59][60][61] mental and psychomotor delay [29,[59][60][61] oxidative stress in the mother and the fetus [61] premature birth, miscarriage [62] problems in the neural tube of the newborn [63] oxidative stress in the premature [43] triggers cardiovascular problems [29] insulin resistance [29] neuronal disorders [22,…”

Section: Influence Of Minerals On Child Growth and Developmentmentioning

confidence: 99%

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Minerals in Pregnancy and Their Impact on Child Growth and Development

et al. 2020

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During pregnancy, women undergo metabolic and physiological changes, and their needs are higher, to maintain growth and development of the fetus. If the nutritional status of the expectant mother is not satisfactory, some maternal and neonatal complications can occur. In the second and third trimester of pregnancy, there is a reserve of nutrients in the fetus that can be utilized after birth; thereby, children present an accelerated growth in the first years of life, which is a proven response to the available nutrition pattern. However, if such a pattern is insufficient, there will be deficits during development, including brain function. Therefore, despite many recent published works about gestational nutrition, uncertainties still remain on the mechanisms of absorption, distribution, and excretion of micronutrients. Further elucidation is needed to better understand the impacts caused either by deficiency or excess of some micronutrients. Thus, to illustrate the contributions of minerals during prenatal development and in children, iodine, selenium, iron, zinc, calcium, and magnesium were selected. Our study sought to review the consequences related to gestational deficiency of the referred minerals and their impact on growth and development in children born from mothers with such deficiencies

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Human biomonitoring to evaluate exposure to toxic and essential trace elements during pregnancy. Part A. concentrations in maternal blood, urine and cord blood.

Cited by 74 publications

References 62 publications

Foetal exposure to heavy metals and risk of atopic diseases in early childhood

Foetal exposure to heavy metals and risk of atopic diseases in early childhood

Maternal Diet During Pregnancy and Blood Cadmium Concentrations in an Observational Cohort of British Women

Minerals in Pregnancy and Their Impact on Child Growth and Development

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