Human Bertielliasis in Amazonia: Case Report and Challenging Diagnosis

Furtado, Adriano Penha; Batista, Evander de Jesus Oliveira; Gonçalves, Evonnildo Costa; Silva, Anderson M. H. O.; Melo, Francisco Tiago de Vasconcelos; Giese, Elane Guerreiro; Santos, Jeannie Nascimento dos

doi:10.1371/journal.pntd.0001580

Cited by 5 publications

(7 citation statements)

References 12 publications

(15 reference statements)

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“…According to the available demographic data, most of the patients resided in Central Province, Sri Lanka; the most likely reason that they comprised most patients is the Bertiella tapeworm reservoir hosts, particularly Ceylon torque monkey (Macaca sinica) and gray langur (Presbytis entellus), that inhabit this region (12,13). Over time, these monkey populations have lost their habitats due to deforestation and rapid urbanization in Sri Lanka; they are now regular visitors in suburban and urban areas scavenging for food near human settlements, which has increased human exposure to B. studeri infection (14,15). Unavailability of molecular data for B. studeri 28S, COX1, and NAD1 markers in GenBank was a constraint that we encountered during phylogenetic analysis.…”

Section: Discussionmentioning

confidence: 99%

Bertiella studeri Infection in Children, Sri Lanka

Amarasinghe¹,

Le²,

Wickramasinghe³

2020

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 99%

Bertiella studeri Infection in Children, Sri Lanka

Amarasinghe¹,

Le²,

Wickramasinghe³

2020

Emerg. Infect. Dis.

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“…In mature proglottids, the vagina is 1.03–1.60 mm long, but may reach 2 mm in width when fully gravid (de Costa et al ., 1967). Reported egg sizes from human cases of B. mucronata vary between 36 and 47 μ m in maximum diameter (Stiles and Hassall, 1902; Cram, 1928; Furtado et al ., 2012). Although eggs of B. mucronata are on average smaller than B. studeri , there is a considerable degree of overlap (Cram, 1928; d’ Alessandro et al ., 1963; de Costa et al ., 1967; Paçô et al ., 2003; Gomez-Puerta et al ., 2009; da Silva et al ., 2011; Lopes et al ., 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Although eggs of B. mucronata are on average smaller than B. studeri , there is a considerable degree of overlap (Cram, 1928; d’ Alessandro et al ., 1963; de Costa et al ., 1967; Paçô et al ., 2003; Gomez-Puerta et al ., 2009; da Silva et al ., 2011; Lopes et al ., 2015). The pyriform apparatus within these eggs has been measured as 21–45 μ m in diameter at the widest point and oncospheres as 9–16 μ m in diameter (d’ Alessandro et al ., 1963; Gomez-Puerta et al ., 2009; Furtado et al ., 2012; Lopes et al ., 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Non-human primate infections have been reported from Peru (Gomez-Puerta et al ., 2009). Many historical case reports did not include clinical history, but one case from Paraguay reported intermittent constipation and diarrhoea (d’ Alessandro et al ., 1963), while another from Brazil reported only nocturnal abdominal distension (Furtado et al ., 2012). Two cases from Brazil presented with marked symptoms of abdominal pain, combined with intermittent vomiting, dyspepsia, anorexia and diarrhoea (Paçô et al ., 2003; da Silva et al ., 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Two cases from Brazil presented with marked symptoms of abdominal pain, combined with intermittent vomiting, dyspepsia, anorexia and diarrhoea (Paçô et al ., 2003; da Silva et al ., 2011). All cases with clinical history reported the passage of tapeworm proglottids and/or strobilae per rectum (d’ Alessandro et al ., 1963; de Souza Júnior et al ., 2008; da Silva et al ., 2011; Furtado et al ., 2012; Lopes et al ., 2015). Recently reported cases of bertiellosis due to B. mucronata for which treatment is described have all been successfully treated with praziquantel (Furtado et al ., 2012; Lopes et al ., 2015).…”

Section: Introductionmentioning

confidence: 99%

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The forgotten exotic tapeworms: a review of uncommon zoonotic Cyclophyllidea

Sapp

Bradbury

2020

Parasitology

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As training in helminthology has declined in the medical microbiology curriculum, many rare species of zoonotic cestodes have fallen into obscurity. Even among specialist practitioners, knowledge of human intestinal cestode infections is often limited to three genera, Taenia, Hymenolepis and Dibothriocephalus. However, five genera of uncommonly encountered zoonotic Cyclophyllidea (Bertiella, Dipylidium, Raillietina, Inermicapsifer and Mesocestoides) may also cause patent intestinal infections in humans worldwide. Due to the limited availability of summarized and taxonomically accurate data, such cases may present a diagnostic dilemma to clinicians and laboratories alike. In this review, historical literature on these cestodes is synthesized and knowledge gaps are highlighted. Clinically relevant taxonomy, nomenclature, life cycles, morphology of human-infecting species are discussed and clarified, along with the clinical presentation, diagnostic features and molecular advances, where available. Due to the limited awareness of these agents and identifying features, it is difficult to assess the true incidence of these ‘forgotten’ cestodiases as clinical misidentifications are likely to occur. Also, the taxonomic status of many of the human-infecting species of these tapeworms is unclear, hampering accurate species identification. Further studies combining molecular data and morphological observations are necessary to resolve these long-standing taxonomic issues and to elucidate other unknown aspects of transmission and ecology.

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Molecular phylogeny of anoplocephalid tapeworms (Cestoda: Anoplocephalidae) infecting humans and non-human primates

et al. 2015

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Anoplocephalid tapeworms of the genus Bertiella Stiles and Hassall, 1902 and Anoplocephala Blanchard, 1848, found in the Asian, African and American non-human primates are presumed to sporadic ape-to-man transmissions. Variable nuclear (5.8S-ITS2; 28S rRNA) and mitochondrial genes (cox1; nad1) of isolates of anoplocephalids originating from different primates (Callicebus oenanthe, Gorilla beringei, Gorilla gorilla, Pan troglodytes and Pongo abelii) and humans from various regions (South America, Africa, South-East Asia) were sequenced. In most analyses, Bertiella formed a monophyletic group within the subfamily Anoplocephalinae, however, the 28S rRNA sequence-based analysis indicated paraphyletic relationship between Bertiella from primates and Australian marsupials and rodents, which should thus be regarded as different taxa. Moreover, isolate determined as Anoplocephala cf. gorillae from mountain gorilla clustered within the Bertiella clade from primates. This either indicates that A. gorillae deserves to be included into the genus Bertiella, or, that an unknown Bertiella species infects also mountain gorillas. The analyses allowed the genetic differentiation of the isolates, albeit with no obvious geographical or host-related patterns. The unexpected genetic diversity of the isolates studied suggests the existence of several Bertiella species in primates and human and calls for revision of the whole group, based both on molecular and morphological data.

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Human Bertielliasis in Amazonia: Case Report and Challenging Diagnosis

Cited by 5 publications

References 12 publications

Bertiella studeri Infection in Children, Sri Lanka

Bertiella studeri Infection in Children, Sri Lanka

The forgotten exotic tapeworms: a review of uncommon zoonotic Cyclophyllidea

Molecular phylogeny of anoplocephalid tapeworms (Cestoda: Anoplocephalidae) infecting humans and non-human primates

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