Human Amniotic Membrane Plug to Restore Age-Related Macular Degeneration Photoreceptor Damage

Rizzo, Stanislao; Caporossi, Tomaso; Tartaro, Ruggero; Finocchio, Lucia; Pacini, Bianca; Bacherini, Daniela; Virgili, Gianni

doi:10.1016/j.oret.2020.04.017

Cited by 17 publications

(16 citation statements)

References 65 publications

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“…End-stage age-related macular degeneration is the leading cause of blindness in the industrialized world and Prof Rizzo’s group for the first time introduced the hAM in the treatment of this degenerative chronic disease [ 35 ].…”

Section: Outcomes Of the Human Amniotic Membrane Retinal Transplanmentioning

confidence: 99%

“…The hAM application for retinal pathologies was extended to treat large macular tears [ 31 ], high myopic retinal detachment associated with MH [ 32 ], paravascular tears [ 33 ], serous macular detachment associated with optic pits [ 34 ], complicated retinal detachment [ 30 ] and advanced age related macular degeneration (AMD) [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

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Applications of the Amniotic Membrane in Vitreoretinal Surgery

Caporossi

Tartaro

Bacherini

et al. 2020

JCM

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Recently, the use of the human amniotic membrane (hAM) has been extended to treat retinal disorders, such as macular holes that failed to close and retinal tears. The hAM has demonstrated the induction of a recovery process of the external retinal layers involving the external limiting membrane (ELM) and the ellipsoid zone (EZ). After that, the application of the hAM for retinal pathologies was extended to large macular tears, high myopic retinal detachment associated with MH, paravascular tears, serous macular detachment associated with optic pit, complicated retinal detachment and advanced age-related macular degeneration (AMD). The hAM has shown a potential in repairing retinal tissue through a regeneration process. This review aims to highlight the use of the hAM in various vitreo-retinal surgical fields, and to confront it with other cutting-edge surgical techniques used to treat challenging vitreo-retinal pathologies.

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Section: Outcomes Of the Human Amniotic Membrane Retinal Transplanmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Applications of the Amniotic Membrane in Vitreoretinal Surgery

Caporossi

Tartaro

Bacherini

et al. 2020

JCM

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“…The first macular holes were tamponed using silicone oil and gas because the authors were concerned about hAM's postoperative dislocation, whereas the most recent cases were tamponed with air only because they understood that the hAM plug was stable inside the macular hole in the postoperative time [89]. Prof Rizzo's group obtained interesting results, using the hAM, also in the end-stage dry and wet age-related macular degeneration treatment [3]. Not only the hAM, positioned under the retina, demonstrated its safety and non-immunogenicity, but it showed a good microperimetry function and photoreceptor cell repopulation (observed using adaptive optics technology) (Fig.…”

Section: Amniotic Membrane In Retinal Pathologiesmentioning

confidence: 99%

“…Moreover, the authors extended the use of hAM in other retinal pathologies such as myopic macular holes associated with retinal detachment [2] and dry and wet age-related macular degeneration [3]. Prof Rizzo and Dr. Caporossi's group have proposed, for the first time, the use of the hAM to treat these pathologies.…”

Section: Introductionmentioning

confidence: 99%

Insights on the Human Amniotic Membrane in Clinical Practice with a Focus on the New Applications in Retinal Surgery

Tartaro

Caporossi

Virgili

et al. 2020

Regen. Eng. Transl. Med.

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Lay SummaryRecently, the use of the human amniotic membrane (hAM) has been extended to treat retinal disorders such as refractory macular holes, retinal breaks and dry and wet age-related macular degeneration. Not only the hAM has proved to be an excellent tool for repairing retinal tissue, but it has also shown a promising regeneration potential. This review aims to highlight the novel use of the hAM in treating retinal diseases. Although the hAM has been used in the ocular anterior segment reconstruction for more than 60 years, in the last 2 years, we have found in literature articles showing the use of the hAM in the retinal surgery field with interesting results in terms of tissue healing and photoreceptor regeneration.

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“…Recently, a new approach involving the use of the human amniotic membrane (hAM) to support the external retinal layers after the extraction of the clot has been proposed, with encouraging results despite the approach being limited to clot removal (Rizzo et al. 2020).…”

Section: Introductionmentioning

confidence: 99%

Management of submacular massive haemorrhage in age‐related macular degeneration: comparison between subretinal transplant of human amniotic membrane and subretinal injection of tissue plasminogen activator

Caporossi¹,

Bacherini

Governatori

et al. 2021

Acta Ophthalmologica

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Macular neovascularization (MNV) can complicate age-related macular degeneration (AMD) and lead to severe visual acuity reduction. Massive submacular haemorrhage (SMH) is a sight-threatening complication of MNV and a challenge in the management of complications related to MNV in AMD since the effects of anti-vascular endothelial growth factor treatment alone are insufficient. Here, we evaluate the different postoperative outcomes of patients affected by MNV complicated by SMH that underwent subretinal implant of human amniotic membrane (hAM) or subretinal injection of tissue plasminogen activator (tPA).Methods: This is a retrospective, consecutive, comparative, non-randomized interventional study. We included 44 eyes of 44 patients affected by AMD complicated by MNV and SMH. Twenty-two eyes underwent a pars plana vitrectomy (PPV), SMH and neovascular membrane removal, with a subretinal implant of hAM and silicone oil, and 22 eyes underwent PPV, subretinal injection of tPA, and 20% sulphur hexafluoride. The primary study outcome was visual acuity improvement. Secondary outcomes were postoperative complications, and MNV recurrence and optical coherence tomography (OCT)-Angiography parameters correlated with best-corrected visual acuity (BCVA).Results: Mean preoperative BCVA was 1.9 logarithm of the minimal angle of resolution (logMAR) in the amniotic membrane-group and 2 logMAR in the tPA-group. The mean final BCVA values were 1.25 and 1.4 logMAR, respectively, with a statistically significant difference. Optical coherence tomography (OCT)-Angiography scan was be used to evaluate the retinal vascularization in the treated eye. Conclusion:Both techniques report similar VA improvements and postoperative complications. However, transplantation of hAM seems to have a significant benefit in inhibiting MNV recurrence.

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Human Amniotic Membrane Plug to Restore Age-Related Macular Degeneration Photoreceptor Damage

Cited by 17 publications

References 65 publications

Applications of the Amniotic Membrane in Vitreoretinal Surgery

Applications of the Amniotic Membrane in Vitreoretinal Surgery

Insights on the Human Amniotic Membrane in Clinical Practice with a Focus on the New Applications in Retinal Surgery

Management of submacular massive haemorrhage in age‐related macular degeneration: comparison between subretinal transplant of human amniotic membrane and subretinal injection of tissue plasminogen activator

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