Human absorption of crude coal tar products

Storer, J. S.

doi:10.1001/archderm.120.7.874

Cited by 15 publications

(12 citation statements)

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“…Dermal Exposure Application of 2% crude coal tar to the skin of humans for 8-hour periods on 2 consecutive days yielded evidence of PAH absorption (Storer et al, 1984 ). Phenanthrene, anthracene, pyrene, and fluoranthene were detected in the blood, but benzo[a]pyrene (which is present in coal tar) was not detected.…”

Section: Absorption Inhalation Exposurementioning

confidence: 99%

Atsdr Evaluation of Health Effects of Chemicals. Iv. Polycyclic Aromatic Hydrocarbons (PAHs): Understanding a Complex Problem

et al. 1996

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Polycyclic Aromatic Hydrocarbons (PAHs) are a group of chemicals that are formed during the incomplete burning of coal, oil, gas, wood, garbage, or other organic substances, such as tobacco and charbroiled meat. There are more than 100 PAHs. PAHs generally occur as complex mixtures (for example, as part of products such as soot), not as single compounds. PAHs are found throughout the environment in the air, water, and soil. As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals, including PAHs (ATSDR, 1995), found at facilities on the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) and which pose the most significant potential threat to human health, as determined by ATSDR and the Environmental Protection Agency (EPA). These profiles include information on health effects of chemicals from different routes and durations of exposure, their potential for exposure, regulations and advisories, and the adequacy of the existing database. Assessing the health effects of PAHs is a major challenge because environmental exposures to these chemicals are usually to complex mixtures of PAHs with other chemicals. The biological consequences of human exposure to mixtures of PAHs depend on the toxicity, carcinogenic and noncarcinogenic, of the individual components of the mixture, the types of interactions among them, and confounding factors that are not thoroughly understood. Also identified are components of exposure and health effects research needed on PAHs that will allow estimation of realistic human health risks posed by exposures to PAHs. The exposure assessment component of research should focus on (1) development of reliable analytical methods for the determination of bioavailable PAHs following ingestion, (2) estimation of bioavailable PAHs from environmental media, particularly the determination of particle-bound PAHs, (3) data on ambient levels of PAHs metabolites in tissues/fluids of control populations, and (4) the need for a critical evaluation of current levels of PAHs found in environmental media including data from hazardous waste sites. The health effects component should focus on obtaining information on (1) the health effects of mixtures of PAHs particularly their noncarcinogenic effects in humans, and (2) their toxicokinetics. This report provides excerpts from the toxicological profile of PAHs (ATSDR, 1995) that contains more detailed information.

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Section: Absorption Inhalation Exposurementioning

confidence: 99%

Atsdr Evaluation of Health Effects of Chemicals. Iv. Polycyclic Aromatic Hydrocarbons (PAHs): Understanding a Complex Problem

et al. 1996

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“…[19][20][21] In human beings, the topical use of coal tar can lead to systemic absorption of polycyclic aromatic hydrocarbon, which is potentially mutagenic. [22][23][24] However, it is not known whether topical application of coal tar is teratogenic in human beings. In one small retrospective study of 17 infants delivered to women who had been treated with topical coal tar during pregnancy, one infant was reported to have been born with a lethal congenital anomaly (trisomy 13).…”

Section: Corticosteroidsmentioning

confidence: 99%

Safety of dermatologic drugs used in pregnant patients with psoriasis and other inflammatory skin diseases

Lam

Polifka

Dohil

2008

Journal of the American Academy of Dermatology

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“…Following eight hours of skin contact in five human volunteers, PAHs were detectable in blood and urine. 38 The absorption of tar components seems to occur in a qualitatively and quantitatively variable manner. 38 The outcomes of 23 pregnancies during which the mother received topical treatment with coal tar did not differ from the outcomes of 59 untreated pregnancies.…”

Section: Management Of Psoriasis During Pregnancymentioning

confidence: 99%

“…38 The absorption of tar components seems to occur in a qualitatively and quantitatively variable manner. 38 The outcomes of 23 pregnancies during which the mother received topical treatment with coal tar did not differ from the outcomes of 59 untreated pregnancies. 39 While it appears there is no strong connection between tar exposure and birth defects in humans, the possibility of infrequent adverse events is not excluded by such a small study.…”

Section: Management Of Psoriasis During Pregnancymentioning

confidence: 99%

Psoriasis and Pregnancy

Tauscher

Fleischer

Phelps

et al. 2002

Journal of Cutaneous Medicine and Surgery: Incorporating Medica

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Topical corticosteroids and topical calcipotriene as well as topical anthralin and topical tacrolimus appear to be safe choices for control of localized psoriasis in pregnancy. UVB is the safest treatment for extensive psoriasis during pregnancy, particularly when topical application of other agents is not practical. Short-term use of cyclosporine during pregnancy is probably the safest option for management of severe psoriasis that has not responded to topical or UVB treatment.

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Human absorption of crude coal tar products

Cited by 15 publications

References 0 publications

Atsdr Evaluation of Health Effects of Chemicals. Iv. Polycyclic Aromatic Hydrocarbons (PAHs): Understanding a Complex Problem

Atsdr Evaluation of Health Effects of Chemicals. Iv. Polycyclic Aromatic Hydrocarbons (PAHs): Understanding a Complex Problem

Safety of dermatologic drugs used in pregnant patients with psoriasis and other inflammatory skin diseases

Psoriasis and Pregnancy

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