Hubungan Resistensi Insulin dengan Gambaran Klinis Sindrom Ovarium Polikistik

Abstract

Abstrak Sindrom Ovarium Polikistik (SOPK) merupakan kelainan endokrin dan metabolik pada wanita usia reproduksi. SOPK merupakan kumpulan gejala dari amenore, oligomenore, infertilitas, obesitas, hirsutisme, acne, alopesia, dan akantosis nigrikan. Resistensi insulin diyakini sebagai salah satu penyebab tersering dari SOPK melalui berbagai mekanisme. Tujuan penelitian ini adalah untuk mengetahui hubungan resistensi insulindengan gambaran klinis SOPK. Penelitian ini dilakukan pada pasien SOPK dengan menggunakan studi cross sectional dengan pendekatan retrospektif, yaitu mengumpulkan kejadian masa lalu dari tahun 2009 - 2011, jumlah sampel 105 orang. Analisis statistik yang digunakan adalah uji chi-square. Hasil penelitian didapatkan 33,3% penderita SOPK mengalami resistensi insulin. Berdasarkan gambaran klinis 35,23% amenore, 64,77% oligomenore, 72,04% infertilitas, 50,5% obesitas, 0,95% hirsutisme, acne 20%, alopesia dan akantosis nigrikan0%. Dari 33,3% SOPK dengan resistensi insulin 40% amenore, 60% oligomenore, 71,9% infertilitas, 77,14% obesitas, dan 0% hirsutisme. Berdasarkan hasil uji statistik ditemukan hubungan bermakna antara resistensi insulin dengan obesitas (p<0,05) dan tidak ditemukan hubungan bermakna antara resistensi insulin dengan infertilitas, hirsutisme, dan acne (p>0,05).Kata Kunci: SOPK, resistensi insulin, gambaran klinisAbstract Polycystic Ovary Syndrome (PCOS) is an endocrine and metabolic disorders that is common in reproductive-aged women. PCOS is a group of symptoms, such as amenorrhea, oligomenorrhea, infertility, obesity, hirsutism, acne, alopecia, and achanthosis nigricans. Insulin resistance is believed to be one of the most common causes of PCOS through a various mechanisms. The objective of this study was to find out the relationship between insulin resistance and clinical manifestation of PCOS. This research was done in patients with PCOS using cross sectional study with retrospective approach. Data was collected from 2009-2011, with the sample of 105 patients. This research used statistical analysis, that was chi square test. This research found that 33.3% patients of PCOS have insulin resistance. Based on clinical manifestation found that 35.23% amenorrhea, 64.77% oligomenorrhea, 72.04% infertility, 50.5% obesity, 0.95% hirsutism, 20% acne, 0% alopecia and achanthosis nigricans. From 33.3% PCOS with insulin resistance, 40% amenorrhea, 60% oligomenorrhea, 71.9% infertility, 77.14% obesity, and 0% hirsutism. The results showed that there is a significant relationship between insulin resistance and obesity (p<0.05) and no significant reslationship between insulin resistance and infertility, hirsutism, and acne (p>0.05).Keyword: PCOS, insulin resistance, clinical manifestation

Correlation of Serum Vitamin D and Metabolic Disturbances in Polycystic Ovarian Syndrome

“…This is in accordance with the study conducted by Wahyuni et al which stated that the age group with the highest prevalence of PCOS is between age 21-30 years old. 7 The mean BMI in this study was 24.78 kg/m2 and almost 80% of the subjects in this study had a waist circumference above the threshold criteria for metabolic syndrome. These results are similar to the study conducted by Musmar et al showed that the mean BMI and waist circumference of patients with PCOS were 23.37±3.85 kg/m2 and 80.08±7.69 cm, respectively.…”

Correlation Luteinizing Hormone (LH)/Follicle Stimulating Hormone (FSH) Ratio with Low Density Lipoprotein (LDL)/ High Density Lipoprotein (HDL) Ratio in Polycystic Ovarium Syndrome (PCOS) Patients

“…The results of this study are in line with the research of Wahyuni et al, which shows that obesity is more likely to experience PCOS, namely 50.5%. 6 Tavares and Barros state that the highest prevalence of patients with metabolic syndrome in each PCOS phenotype in Brazil has a BMI>30 kg/m 2 (obese).…”

Insulin Resistance in Obese Women: Does it Affect Fertility?

“…From the results of the statistical test, it was concluded that there was a signifi cant relationship between insulin resistance and obesity (p <0.05) and there was a signifi cant relationship between insulin resistance and infertility (p <0.05). 7 The prevalence of insulin resistance for the normal BMI group (18.5-24.9 kg / m2), overweight (25-29.9 kg / m2) and obesity (≥30 kg / m2) is 19.3%, 56.2% and 78.2%, respectively. Being overweight and obese increases insulin resistance by OR 5.3 in overweight and OR 14.9 in obesity.…”

“…The result of the study show obesity and infertility can be affected by insulin resistance. 7 Based on this background the researcher wanted to fi nd out how the description of insulin resistance and BMI and the correlation of insulin resistance with BMI in obese female infertility.…”