“…The study by Teeyapun et al compared the Ab titers between cancer patients and health volunteers following two doses of ChAdOx1 vaccine and found lower seroconversion rates of 60.8 and 78.9% after 4 and 8 to 10 weeks following the first dose and 93.6% after 4 weeks following the second dose as opposed to 97.1, 98.9, and 100%, respectively, in healthy volunteers. 12 This is also in line with our other data (unpublished) that show that cancer patients have lower Ab titers following the administration of the ChAdOx1 vaccine as compared to healthy volunteers. From the efficacy point of view, only 2 of 56 patients had Covid infection (confirmed by RT-PCR) within 21 days of taking their first dose.…”
Covid-19 has led to significant mortality worldwide, with an increased risk in cancer patients. Vaccination provides significant protection against the infection. The study focuses on the immunogenicity and effectiveness of ChAdOx1 nCoV-19 vaccine in cancer patients within a real-world setting. Blood samples for measuring Covid antibody titers against the receptor binding domain were collected according to a convenient sparse sampling strategy in a real-world setting, with the days of the collection coinciding with their hospital appointment. The antibody titers between different groups were analyzed descriptively. A total of 56 patients were enrolled in the study. There was no apparent effect in antibody titers between patients with solid tumors and hematological malignancies (mean ± standard deviation [SD]: 36.80 ± 41.18 vs. 52.02 ± 26.27), among patients who were undergoing chemotherapy, immunotherapy, or local therapy (mean ± SD: 42.50 ± 44.46 vs. 50.06 ± 51.39 vs. 28.70 ± 25.03), and in patients with up to 90 days and more than 90 days' interval between their last treatment and date of vaccination (mean ± SD: 38.96 ± 42.66 vs. 40.51 ± 38.65). Additionally, there were only 2/56 patients with breakthrough infection, which points out the effectiveness of this vaccine in cancer patients. The ChAdOx1 nCoV-19 vaccine has activity in cancer regardless of the tumor type, type of treatment, or time from the last treatment.
“…The study by Teeyapun et al compared the Ab titers between cancer patients and health volunteers following two doses of ChAdOx1 vaccine and found lower seroconversion rates of 60.8 and 78.9% after 4 and 8 to 10 weeks following the first dose and 93.6% after 4 weeks following the second dose as opposed to 97.1, 98.9, and 100%, respectively, in healthy volunteers. 12 This is also in line with our other data (unpublished) that show that cancer patients have lower Ab titers following the administration of the ChAdOx1 vaccine as compared to healthy volunteers. From the efficacy point of view, only 2 of 56 patients had Covid infection (confirmed by RT-PCR) within 21 days of taking their first dose.…”
Covid-19 has led to significant mortality worldwide, with an increased risk in cancer patients. Vaccination provides significant protection against the infection. The study focuses on the immunogenicity and effectiveness of ChAdOx1 nCoV-19 vaccine in cancer patients within a real-world setting. Blood samples for measuring Covid antibody titers against the receptor binding domain were collected according to a convenient sparse sampling strategy in a real-world setting, with the days of the collection coinciding with their hospital appointment. The antibody titers between different groups were analyzed descriptively. A total of 56 patients were enrolled in the study. There was no apparent effect in antibody titers between patients with solid tumors and hematological malignancies (mean ± standard deviation [SD]: 36.80 ± 41.18 vs. 52.02 ± 26.27), among patients who were undergoing chemotherapy, immunotherapy, or local therapy (mean ± SD: 42.50 ± 44.46 vs. 50.06 ± 51.39 vs. 28.70 ± 25.03), and in patients with up to 90 days and more than 90 days' interval between their last treatment and date of vaccination (mean ± SD: 38.96 ± 42.66 vs. 40.51 ± 38.65). Additionally, there were only 2/56 patients with breakthrough infection, which points out the effectiveness of this vaccine in cancer patients. The ChAdOx1 nCoV-19 vaccine has activity in cancer regardless of the tumor type, type of treatment, or time from the last treatment.
“…The result of the immunogenicity testing was reported in an earlier study. 23 In this study, we also collected the incidence of COVID-19 infection, which was detected using an antigen test kit or a nasopharyngeal polymerase chain reaction (PCR) after each dose of vaccine. Figure 1.…”
The study aimed to evaluate vaccine-related adverse events (VRAEs) following ChAdOx1-nCoV-19 vaccine in solid cancer patients receiving treatment compared to healthy controls. 399 cancer patients and 90 healthy volunteers were enrolled. In the overall population, the incidence of VRAEs was significantly lower in cancer patients than in healthy volunteers (57% vs 80%,
P
< .001). Because the mean age of the cancer patients was higher than the healthy volunteers (59 vs 48 years,
P
< .001), we analyzed age-matched comparison and found that there was no significant difference of VRAEs between two groups (74% vs 79%,
P
.32). Most VRAEs were of mild severity in both groups. The most common local VRAE was pain at the injection site in both groups, and the most common systemic VRAE was fatigue in the cancer cohort, while myalgia was the most common VRAE among the healthy controls. In the cancer cohort, fever was the only VRAE that led to interruption of the cancer treatment (in two cases). Among the cancer treatment types, patients undergoing chemotherapy-containing regimens had a lower likelihood of experiencing VRAEs. In summary, the overall incidence of VRAEs following ChAdOx1-nCoV-19 vaccine in actively treated cancer patients was comparable to healthy controls after adjusting for age. The VRAEs that occurred rarely interfered with the cancer treatment. These findings substantiate that vaccination with AZD1222 is safe in cancer patients undergoing treatment.
“…Greater than 190,000 people were diagnosed with cancer in 2020 3 . The two most common cancers originated in the liver (27,394 new cases/ year) and the lung (23,713 new cases/year). Genetic testing for cancer biomarkers in this country has evolved over the past two decades.…”
Section: The Landscape Of Genomic Medicine In Thailandmentioning
confidence: 99%
“…During the COVID-19 pandemic, a group of oncologists conducted a prospective multicenter study on the immunogenicity of the ChAdOx1-nCoV-19 vaccine in hundreds of patients with solid malignancies who received chemotherapy, targeted therapy, or immunotherapy compared to healthy controls. The study addressed several issues related to the immune response of cancer patients who receive antineoplastic agents 27 . The project demonstrated a model of collaborative efforts in adaptation to the crisis among oncologists in academic universities and community oncologists.…”
Section: Clinical Trial Network In Thailand: Initial Development Of A...mentioning
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