HSPA5 and FGFR1 genes in the mesenchymal subtype of glioblastoma can improve a treatment efficacy
Ju Young Lee,
Jongkeun Park,
Dongwan Hong
Abstract:Tyrosine kinase inhibitors (TKIs) have emerged as a potential treatment strategy for glioblastoma multiforme (GBM). However, their efficacy is limited by various drug resistance mechanisms. To devise more effective treatments for GBM, genetic characteristics must be considered in addition to pre-existing treatments. We performed an integrative analysis with heterogeneous GBM datasets of genomic, transcriptomic, and proteomic data from DepMap, TCGA and CPTAC. We found that poor prognosis was induced by co-upreg… Show more
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