Biochemical Pharmacology volume 77, issue 3, P375-383 2009 DOI: 10.1016/j.bcp.2008.10.019 View full text
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Raphael Beck, Julien Verrax, Thomas Gonze, Marianne Zappone, Rozangela Curi Pedrosa, Henryk Taper, Olivier Feron, Pedro Buc Calderon

Abstract: The heat shock protein 90 (Hsp90) plays a crucial role in the stability of several proteins that are essential for malignant transformation. Hsp90 is therefore an interesting therapeutic target for cancer therapy. In this paper, we investigated whether an oxidative stress generated during ascorbate-driven menadione redox cycling (ascorbate/menadione), affects Hsp90 leading to the degradation of some critical proteins and cell death. Unlike 17-AAG, which inhibits Hsp90 but enhances Hsp70 levels, ascorbate/menad…

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