Biochemical Pharmacology volume 77, issue 10, P1635-1641 2009 DOI: 10.1016/j.bcp.2009.02.019 View full text
Sushma Yadav, Jyotsana Singhal, Sharad S. Singhal, Sanjay Awasthi

Abstract: AbstractHistone-methyl transferases (HMTs) are key enzymes that post-translationally modify histones, and serve key role in gene expression, epigenetic regulation, and as determinants of survival in malignant cells. Recent studies have shed light on the role of hSET1 which is a key element of highly conserved multi-protein HMT complex that catalyze methylation of histone H3 lysine 4 (H3K4) regulating expression of specific proteins important for the malignant phenotype. To understand the importance of differe…

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