hsa-miRNA-154-5p expression in plasma of endometriosis patients is a potential diagnostic marker for the disease

Pateisky, Petra; Pils, Dietmar; Szabo, Ladislaus; Kuessel, Lorenz; Husslein, H; Schmitz, Arndt; Wenzl, René; Yotova, Iveta

doi:10.1016/j.rbmo.2018.05.007

Cited by 47 publications

(47 citation statements)

References 75 publications

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“…However, the clinical utility of the combined endometriosis diagnostic test is still unclear due to the limitations and heterogeneity of the included studies. Recently, Pateisky et al [ 46 ] found in a prospective cohort study that specific plasma miRNA characteristics were associated with endometriosis and that hsa-miR-154-5p alone or combined with other types may be potentially applicable for non-invasive diagnosis of the disease. In summary, it is greatly worthwhile and essential to further evaluate the diagnostic potential of any type of combined test that has been identified in a few studies as potentially valuable for the detection of endometriosis.…”

Section: Combined Testmentioning

confidence: 99%

Current biomarkers for the detection of endometriosis

Tian

Chang

Zhao

et al. 2020

Chinese Medical Journal

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A clinically reliable non-invasive test for endometriosis is expected to reduce the diagnostic delay. Although varieties of biomarkers have been investigated for decades, and cancer antigen-125, cancer antigen-199, interleukin-6, and urocortin were the most studied ones among hundreds of biomarkers, no clinically reliable biomarkers have been confirmed so far. Some emerging technologies including “omics” technologies, molecular imaging techniques, and microRNAs are promising in solving these challenges, but their utility to detect endometriosis has yet to be verified. New combinations of researched indicators or other non-invasive methods and further exploration of the emerging technologies may be new targets and future research hotspots for non-invasive diagnosis of endometriosis. In conclusion, researches of biomarkers for the detection of endometriosis are still ongoing and may benefit from novel molecular biology, bioinformatics methods and a combination of more diverse monitoring methods. Though it will be a daunting task, the identification of a specific set of diagnostic biomarkers will undoubtedly improve the status of endometriosis.

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Section: Combined Testmentioning

confidence: 99%

Current biomarkers for the detection of endometriosis

Tian

Chang

Zhao

et al. 2020

Chinese Medical Journal

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“…A recent prospective study reported that both miR-199a and miR-122 were upregulated in serum from women with endometriosis, showing high specificity for endometriosis [72], while a different group had reported significant downregulation of miR-199a in the serum of women with endometriosis [66]. The following other circulating miRNAs have been suggested as biomarkers in publications from 2018: miR-17 [126], miR-31 [74], and miR-154-5p [127]. A summary of the published AUC values for circulating miRNA biomarkers in endometriosis can be found in the 2018 review by Argawal et al [53].…”

Section: Additional Circulating Mirna Biomarkersmentioning

confidence: 99%

MicroRNAs in endometriosis: biological function and emerging biomarker candidates†

Björkman

Taylor

2019

Biology of Reproduction

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MicroRNAs (miRNAs), a class of small noncoding RNA molecules, have been recognized as key post-transcriptional regulators associated with a multitude of human diseases. Global expression profiling studies have uncovered hundreds of miRNAs that are dysregulated in several diseases, and yielded many candidate biomarkers. This review will focus on miRNAs in endometriosis, a common chronic disease affecting nearly 10% of reproductive-aged women, which can cause pelvic pain, infertility, and a myriad of other symptoms. Endometriosis has delayed time to diagnosis when compared to other chronic diseases, as there is no current accurate, easily accessible, and noninvasive tool for diagnosis. Specific miRNAs have been identified as potential biomarkers for this disease in multiple studies. These and other miRNAs have been linked to target genes and functional pathways in disease-specific pathophysiology. Highlighting investigations into the roles of tissue and circulating miRNAs in endometriosis, published through June 2018, this review summarizes new connections between miRNA expression and the pathophysiology of endometriosis, including impacts on fertility. Future applications of miRNA biomarkers for precision medicine in diagnosing and managing endometriosis treatment are also discussed.

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“…Samples, collected from 2010 to 2015, were selected from prospectively enrolled patients of the Endometriosis Marker Austria (EMMA) study, a prospective cohort study conducted at the tertiary referral certified Endometriosis Centre of the Medical University of Vienna [ 28 ]. The study was approved by the ethics committee of the Medical University of Vienna (EK 545/2010).…”

Section: Methodsmentioning

confidence: 99%

Does the Use of the “Proseek® Multiplex Oncology I Panel” on Peritoneal Fluid Allow a Better Insight in the Pathophysiology of Endometriosis, and in Particular Deep-Infiltrating Endometriosis?

Perricos

Wenzl

Husslein

et al. 2020

JCM

Self Cite

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Endometriosis appears to share certain cancer-related processes, such as cell attachment, invasion, proliferation and neovascularization, some of which can also be found in other healthy tissues. In order to better understand the altered milieu of the peritoneal cavity, while acknowledging the reported similarities between endometriosis and neoplastic processes, we applied a multiplex oncology panel to search for specific biomarker signatures in the peritoneal fluid of women with endometriosis, women with deep-infiltrating endometriosis (DIE), as well as controls. In total, 84 patients were included in our study, 53 women with endometriosis and 31 controls. Ninety-two proteins were measured in prospectively collected peritoneal fluid (PF) samples, using the “Proseek® Multiplex Oncology I Panel”. We first compared patients with endometriosis versus controls, and in a second step, DIE versus endometriosis patients without DIE. Out of the 92 analyzed proteins, few showed significant differences between the groups. In patients with endometriosis, ICOS ligand, Endothelial growth factor, E-selectin, Receptor tyrosine-protein kinase erbB-2, Interleukin-6 receptor alpha, Vascular endothelial growth factor receptor 2, Fms-related tyrosine kinase 3 ligand, C-X-C motif chemokine 10, Epididymal secretory protein E4 and Folate receptor-alpha were decreased, while Interleukin-6 and Interleukin-8 were increased compared to controls. Looking at patients with DIE, we found Chemokine ligand 19, Stem cell factor, Vascular endothelial growth factor D, Interleukin-6 receptor alpha and Melanoma inhibitory activity to be increased compared to endometriosis patients without DIE. We have shown a distinct regulation of the immune response, angiogenesis, cell proliferation, cell adhesion and inhibition of apoptosis in PF of patients with endometriosis compared to controls. The specific protein pattern in the PF of DIE patients provides new evidence that DIE represents a unique entity of extrauterine endometriosis with enhanced angiogenetic and pro-proliferative features.

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hsa-miRNA-154-5p expression in plasma of endometriosis patients is a potential diagnostic marker for the disease

Cited by 47 publications

References 75 publications

Current biomarkers for the detection of endometriosis

Current biomarkers for the detection of endometriosis

MicroRNAs in endometriosis: biological function and emerging biomarker candidates†

Does the Use of the “Proseek® Multiplex Oncology I Panel” on Peritoneal Fluid Allow a Better Insight in the Pathophysiology of Endometriosis, and in Particular Deep-Infiltrating Endometriosis?

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