HSA immobilized novel polymeric matrix as an alternative sorbent in hemoperfusion columns for bilirubin removal

Kavoshchian, Mahdi; Üzek, Recep; Uyanık, Sadık Ahmet; Şenel, Serap; Deni̇zli̇, Adil

doi:10.1016/j.reactfunctpolym.2015.09.004

Cited by 32 publications

(11 citation statements)

References 38 publications

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“…They characterized the composite cryogels by various analyses and then performed the removal of bilirubin from plasma samples. They analyzed several parameters that affect the adsorption capacity of composite cryogel, including incubation time, albumin concentration, bilirubin concentration in plasma, and temperature, and found that the maximum bilirubin removal from plasma was 25.4 mg/g at 37.5 °C [58].…”

Section: Composite Cryogels As Versatile Tools For Biomedical Applmentioning

confidence: 99%

Supermacroporous Composite Cryogels in Biomedical Applications

Saylan

Denizli

2019

Gels

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Supermacroporous gels, called cryogels, are unique scaffolds that can be prepared by polymerization of monomer solution under sub-zero temperatures. They are widely used in many applications and have significant potential biomaterials, especially for biomedical applications due to their inherent interconnected supermacroporous structures and easy formation of composite polymers in comparison to other porous polymer synthesis techniques. This review highlights the fundamentals of supermacroporous cryogels and composite cryogels, and then comprehensively summarizes recent studies in preparation, functionalization, and utilization with mechanical, biological and physicochemical features, according to the biomedical applications. Furthermore, conclusions and outlooks are discussed for the use of these promising and durable supermacroporous composite cryogels.

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Section: Composite Cryogels As Versatile Tools For Biomedical Applmentioning

confidence: 99%

Supermacroporous Composite Cryogels in Biomedical Applications

Saylan

Denizli

2019

Gels

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“…it is one of the sensitive indexes of liver function level, with a molecular weight of 584.7 Da. [1] Bilirubin mainly exists and transports in the form of the bilirubin-albumin complex in plasma. Its primary metabolic process is completed in the liver.…”

Section: Introductionmentioning

confidence: 99%

“…Bilirubin (BR) is a metabolite of haemoglobin in ageing red blood cells. it is one of the sensitive indexes of liver function level, with a molecular weight of 584.7 Da [1] . Bilirubin mainly exists and transports in the form of the bilirubin‐albumin complex in plasma.…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Adsorption of Bilirubin by Ti₃C₂T_x MXene

Sun

Yang

et al. 2021

Chemistry An Asian Journal

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We discovered that the 2D Ti 3 C 2 T x MXene sheet displays an ultra-high removal capability for bilirubin (BR). In particular, MXene shows 47.6 times higher removal efficiency over traditional activated carbon absorbents. The effect of MXene on the removal rate of BR in BR solution containing different concentrations of bovine serum albumin (BSA) was studied. The adsorption capacity of BSA for BR at high concentration of 5 g L À 1 was about 85% of the best adsorption capacity. The MXene before and after adsorption was characterized by SEM, FT-IR and XPS. Furthermore, MXene beads were prepared, and the hemoperfusion simulation experiment was carried out. The results show that the adsorption capacity of MXene for bilirubin can reach 1192.9 mg g À 1 . This study suggests that MXene may be promising in the treatment of hyperbilirubinemia.

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“…9 Kavoshchian et al have examined the human serum albumin (HSA) immobilized poly(2hydroxyethyl methacrylate) as an alternative sorbent in hemoperfusion columns that achieved a maximum bilirubin removal of 25.4 mg/g at 37.5 °C. 20 These adsorbents exhibited good hemocompatibility and have been applied in clinics. However, there is a challenge for improving the removal rate of bilirubin and decreasing patient costs.…”

Section: Introductionmentioning

confidence: 99%

“…For example, Timin et al modified the hybrid-silica materials with octyl, phenyl, and urea-propyl functional groups or the guanidine-containing polymers to increase the bilirubin adsorption capacity. , Jiang et al found that amino-grafted PES/PGMA (poly(ether sulfone)/poly(glycidyl methacrylate)) particles have shown great potential for the removal of bilirubin . Kavoshchian et al have examined the human serum albumin (HSA) immobilized poly(2-hydroxyethyl methacrylate) as an alternative sorbent in hemoperfusion columns that achieved a maximum bilirubin removal of 25.4 mg/g at 37.5 °C . These adsorbents exhibited good hemocompatibility and have been applied in clinics.…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Self-Assembled β-Cyclodextrin-Modified Surface for Blood Purification

Liu

Zhong

Chen

et al. 2017

ACS Biomater. Sci. Eng.

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For patients with liver failure, bilirubin (BR) is one of the endogenous toxins in their blood. Although blood purification can remove the bilirubin from the body in clinics, the detoxification system needs to be improved, and the cost needs to be decreased. In the present study, we developed a recyclable model surface that can strongly remove bilirubin. We first prepared adamantane (Ad) on a model gold surface by self-assembly. Then, we integrated the β-cyclodextrin dimer (CDD) onto the surface with host−guest interactions between one of the CD cavities in the CDD and Ad. We characterized the surface with XPS, static contact angle measurements, and AFM. In addition, we employed QCM-D to characterize the preparation process as well as the detoxification of the surface. We demonstrated that this modified surface could strongly adsorb bilirubin through host−guest interactions between the CD cavities in the CDD and bilirubin and that the detoxification was improved 1.7 times (compared to the surface only with Ad). Interestingly, after characterization with QCM-D, this surface could be recycled due to the thermoresponsive property of the host−guest interaction between the CDD and Ad. After adsorbing the toxin and increasing the temperature to 45 °C, the CDD with bilirubin could be removed from the surface. Then, the refreshed surface with CDD could be prepared again at room temperature. This cycle could be repeated at least 3 times. Additionally, during each cycle, the modified surface exhibited good detoxification to bilirubin. This modified surface also showed strong resistance to plasma proteins, decreasing the adsorption of human serum albumin (HSA) and fibrinogen (Fg). An in vitro platelet adhesion assay showed that the adhesion of the platelets on the modified surface decreased and that the platelets were in an inactivated state. The hemolysis assay showed that this surface exhibited no hemolysis activity in the samples to red blood cells (RBCs). The CCK-8 assay showed that this surface had negligible cytotoxicity to L929 cells. This work has taken advantage of the host−guest self-assembly between β-CD and BR/Ad for special recognizing adsorption, as well as the thermoresponse of β-CD-Ad inclusion for recyclable application, and these results demonstrate that this technology has great potential for removing bilirubin and decreasing clinic costs.

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HSA immobilized novel polymeric matrix as an alternative sorbent in hemoperfusion columns for bilirubin removal

Cited by 32 publications

References 38 publications

Supermacroporous Composite Cryogels in Biomedical Applications

Supermacroporous Composite Cryogels in Biomedical Applications

Highly Efficient Adsorption of Bilirubin by Ti₃C₂T_x MXene

Thermoresponsive Self-Assembled β-Cyclodextrin-Modified Surface for Blood Purification

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HSA immobilized novel polymeric matrix as an alternative sorbent in hemoperfusion columns for bilirubin removal

Cited by 32 publications

References 38 publications

Supermacroporous Composite Cryogels in Biomedical Applications

Supermacroporous Composite Cryogels in Biomedical Applications

Highly Efficient Adsorption of Bilirubin by Ti3C2Tx MXene

Thermoresponsive Self-Assembled β-Cyclodextrin-Modified Surface for Blood Purification

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Highly Efficient Adsorption of Bilirubin by Ti₃C₂T_x MXene