HPV Vaccines—Prophylactic, Not Therapeutic

Immune Response Following Quadrivalent Human Papillomavirus Vaccination in Women After Hematopoietic Allogeneic Stem Cell Transplant

“…This approach follows clinical guidelines to administer HPV vaccine regardless of current HPV infection . The vaccine would not have a therapeutic effect against types currently causing HPV disease yet can boost immunity to other vaccine types and possibly protect against de novo exposure to new HPV infections.…”

Incidence and risk factors of second primary cancer after the initial primary human papillomavirus related neoplasms

“…Considering the carcinogenic effect of HPV in both the IPC and its potential carcinogenic effect in second primary HPV-related cancer, the HPV vaccine is promoted for the prevention of HPV infection, and thus HPV-related IPC based on the benefit of HPV vaccination claimed by Nicol et al 50 However, this approved and currently utilized HPV vaccine is not intended for the elimination of HPV and transformed cells. 51,52 E6 and E7 proteins are necessary in the carcinogenic process of HPV and expressed by HPV-transformed cells. Recently, there have been studies of therapeutic vaccines for established HPV infections and malignancies that target E6 and E7 proteins.…”

“… 50 However, this approved and currently utilized HPV vaccine is not intended for the elimination of HPV and transformed cells. 51 , 52 E6 and E7 proteins are necessary in the carcinogenic process of HPV and expressed by HPV‐transformed cells. Recently, there have been studies of therapeutic vaccines for established HPV infections and malignancies that target E6 and E7 proteins.…”

Prevalencia de anormalidades de células epiteliales y factores asociados en mujeres de un municipio rural colombiano

“…Se ha documentado que las vacunas profilácticas que están siendo introducidas en todo el mundo son muy efectivas en mujeres sin previa exposición a la infección con el virus del papiloma humano (23,24) y que estas vacunas no son terapéuticas, o sea, no tienen la capacidad de eliminar infecciones adquiridas (25,26). Es necesario llevar a cabo encuestas de prevalencia del virus del papiloma humano en poblaciones de adolescentes para determinar la edad a la cual se adquieren estas infecciones, de manera que se obtengan los mayores beneficios en la eventualidad de la introducción masiva de estas vacunas.…”