HPLC in the discovery of plant phenolics as antifungal molecules against Candida infection related biofilms

Jaiswal, Neha; Kumar, Awanish

doi:10.1016/j.microc.2022.107572

Cited by 5 publications

(3 citation statements)

References 73 publications

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“…Polypeptide content was determined using an automatic kjeldahl nitrogen analyzer (OLB9870, Olabo, Shenzhen, China) according to the method in [35]. The molecular weight of T-ES was determined using HPLC, according to the method in [36], with a BRT105-104-102 gel column (8 × 300 mm), a 0.05 M NaCl mobile phase (0.6 mL/min), 40 • C column temperature, 20 µL injection volume, and an RI-10A differential detector.…”

Section: Determination Of General Propertiesmentioning

confidence: 99%

Structural Characterization and Anti-Osteoporosis Effects of a Novel Sialoglycopeptide from Tuna Eggs

Hu,

Wan,

Zhu

et al. 2023

Marine Drugs

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Several sialoglycopeptides were isolated from several fish eggs and exerted anti-osteoporosis effects. However, few papers have explored sialoglycopeptide from tuna eggs (T-ES). Here, a novel T-ES was prepared through extraction with KCl solution and subsequent enzymolysis. Pure T-ES was obtained through DEAE-Sepharose ion exchange chromatography and sephacryl S-300 gel filtration chromatography. The T-ES was composed of 14.07% protein, 73.54% hexose, and 8.28% Neu5Ac, with a molecular weight of 9481 Da. The backbone carbohydrate in the T-ES was →4)-β-D-GlcN-(1→3)-α-D-GalN-(1→3)-β-D-Glc-(1→2)-α-D-Gal-(1→2)-α-D-Gal-(1→3)-α-D-Man-(1→, with two branches of β-D-GlcN-(1→ and α-D-GalN-(1→ linking at o-4 in →2,4)-α-D-Gal-(1→. Neu5Ac in the T-ES was linked to the branch of α-D-GlcN-(1→. A peptide chain, Ala-Asp-Asn-Lys-Ser*-Met-Ile that was connected to the carbohydrate chain through O-glycosylation at the –OH of serine. Furthermore, in vitro data revealed that T-ES could remarkably enhance bone density, bone biomechanical properties, and bone microstructure in SAMP mice. The T-ES elevated serum osteogenesis-related markers and reduced bone resorption-related markers in serum and urine. The present study’s results demonstrated that T-ES, a novel sialoglycopeptide, showed significant anti-osteoporosis effects, which will accelerate the utilization of T-ES as an alternative marine drug or functional food for anti-osteoporosis.

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Section: Determination Of General Propertiesmentioning

confidence: 99%

Structural Characterization and Anti-Osteoporosis Effects of a Novel Sialoglycopeptide from Tuna Eggs

Hu,

Wan,

Zhu

et al. 2023

Marine Drugs

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“…Plant phenolics are considered promising antibiofilm and antifungal agents [ 30 , 31 ]. Diaz et al [ 32 ] also reported that the levels of phenolic and flavonoid compounds were correlated with the anti-inflammatory and antioxidant activities of medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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“…It closely resembles the idea of sustainable green development. , Plant polyphenols already have a substantial impact on the food and healthcare sectors. Plant polyphenols including catechins, epigallocatechin gallate, and black wattle tannins have been found to have excellent resistance to Pseudomonas aeruginosa in the preparation of advanced anti-biofilm materials, and flavonoids are the main phenolic components used for the treatment of candidiasis . Polyphenol-rich cranberry extracts have been reported to have antibacterial activity against numerous Listeria species in food safety or freshness preservation .…”

Section: Introductionmentioning

confidence: 99%

High-Value Utilization of Polyphenol Aromatic Antimicrobial Agents Extracted from Pineapple Peel Waste

Zhou

Huma

Tan

2023

ACS Food Sci. Technol.

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Plant polyphenols' antibacterial capabilities are just beginning to be applied in the environment. In this study, solvent recovery and concentration techniques were used to achieve zero-waste extraction of pineapple peel polyphenol (PPP) powder on an industrial scale. For environmental sterilization, PPP antibacterial agents (PAAs) were created. Their physicochemical and antibacterial qualities were examined, and technical and financial analysis was done. The results showed that (1) among the major PPP components, protocatechuic acid content was the highest (48.90 mg/L), followed by quercetin dihydrate (17.56 mg/L); (2) PAA sprays passed the tests for physicochemical properties like pH and heat resistance; (3) at the 8 mg/mL concentration, PAA achieved 100% bacterial inhibition below 40 °C; and (4) the production cost of 8 mg/mL PAA spray was only $273.41/t at 100,000 t industrial scale. These findings might offer an application prospect in the development of renewable bacteriocins from fruit and vegetable waste materials.

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HPLC in the discovery of plant phenolics as antifungal molecules against Candida infection related biofilms

Cited by 5 publications

References 73 publications

Structural Characterization and Anti-Osteoporosis Effects of a Novel Sialoglycopeptide from Tuna Eggs

Structural Characterization and Anti-Osteoporosis Effects of a Novel Sialoglycopeptide from Tuna Eggs

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

High-Value Utilization of Polyphenol Aromatic Antimicrobial Agents Extracted from Pineapple Peel Waste

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