2005
DOI: 10.1074/jbc.c500229200
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Abstract: Histone lysine methylation can have positive or negative effects on transcription, depending on the precise methylation site. According to the "histone code" hypothesis these methylation marks can be read by proteins that bind them specifically and then regulate downstream events. Hetero-chromatin protein 1 (HP1), an essential component of heterochromatin, binds specifically to methylated Lys 9 of histone H3 (K9/H3). The linker histone H1.4 is methylated on Lys 26 (K26/H1.4), but the role of this methylation i… Show more

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Cited by 206 publications
(196 citation statements)
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“…This structural flexibility could allow interaction with distinct protein binding partners as suggested in the case of Msx1 and HP1 (47,48). Recent studies have also mapped distinct post-translational modifications within the N-terminal domains of H1 (49,50).…”
Section: Discussionmentioning
confidence: 97%
“…This structural flexibility could allow interaction with distinct protein binding partners as suggested in the case of Msx1 and HP1 (47,48). Recent studies have also mapped distinct post-translational modifications within the N-terminal domains of H1 (49,50).…”
Section: Discussionmentioning
confidence: 97%
“…(iii) The status of the chromatin template itself might be an important regulator, e.g. linker histones of the H1 type could preclude or enhance HP1 binding either directly (12,19,20) or indirectly by modulating chromatin structure (51). (iv) Timing of interaction within the cell cycle could allow or prevent certain types of binding (12,17).…”
Section: Discussionmentioning
confidence: 99%
“…Interactions between hHP1s with the core region of H3 (12,16,17), of hHP1␣ with H2A.Z (18), of hHP1␣ with linker histone H1 (12,19,20), and of human or Xenopus HP1␣ with DNA (19,21,22) or RNA (23) have been reported. In addition, it has been questioned whether DmHP1 makes stable contacts with chromatin in the absence of accessory factors (24).…”
mentioning
confidence: 99%
“…HP1 proteins dimerise via their C-terminal chromoshadow domains to form a bivalent chromatin binder. Interestingly, HP1 also binds to methylated H1.4K26 via its chromodomain [70]. Since H1.4 is also involved in heterochromatin architecture, it is tempting to speculate that HP1 dimers integrate this positional information (H3K9me and H1.4K26me) in a manner that is important for chromatin compaction.…”
Section: Regulating the Binding Of Chromatin Factorsmentioning
confidence: 99%