HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2

Li, Yuehui; X, Yang; Fang, Shu Juang; Qin, Chang Fei; Sun, Rui; Liu, Zhaoyang; Jiang, Bin Yuan; Wu, Xiang; Li, Guancheng

doi:10.3892/or.2014.3668

Cited by 35 publications

(29 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, an increasing number of studies have indicated that HOX genes play important roles in oncogenesis [23–25]. Many cancers exhibit altered HOX gene expression, particularly leukemia, breast, prostate and lung carcinomas [26–30].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

RETRACTED ARTICLE: HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail

Tang

Sun

et al. 2016

Mol Cancer

View full text Add to dashboard Cite

BackgroundLiver cancer is one of the main causes of cancer-related death in human. HOXA7 has been proved to be related with several cancers.MethodThe expression levels of HOXA7 were examined by Western blot, qRT-PCR or ICH. MTT was used to detect the proliferative rate of liver cancer cells. The invasive abilities were examined by matrigel and transwell assay. The metastatic abilities of liver cancer cells were revealed in BALB/c nude mice.ResultsIn this report, we revealed that HOXA7 promoted metastasis of HCC patients. First, increased levels of HOXA7 were examined in liver cancer especially in metastatic liver cancer. Moreover, higher expression level of HOXA7 was associated with poorer prognosis of liver cancer patients. Overexpression of HOXA7 significantly enhanced proliferation, migration, invasion in vitro and tumor growth and metastasis in vivo meanwhile silencing HOXA7 significantly inhibited the aboves abilities of liver cancer cells. In this research, we identified that HOXA7 performed its oncogenic characteristics through activating Snail.ConclusionCollectively, we identify the critical role and possible mechanism of HOXA7 in metastasis of liver cancer which suggest that HOXA7 may be a potential therapeutic target of liver cancer patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s12943-016-0540-4) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Many cancers exhibit altered HOX gene expression, particularly leukemia, breast, prostate and lung carcinomas [26–30]. It has been reported that HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2 [25]. However, the specific functional role of HOXA7 in liver cancer remains unclear.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail

Tang

Sun

et al. 2016

Mol Cancer

View full text Add to dashboard Cite

show abstract

“…Cyclins act as (i) regulators of specific kinases and (ii) contribute to the coordination of mitotic events. In many tumors overexpression of this gene has been observed 112 . It was recently shown that proliferation of 3T3-L1 preadipocytes promoted by recombinant myostatin increased expression of proliferation related genes (e.g.…”

Section: Discussionmentioning

confidence: 99%

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

et al. 2016

View full text Add to dashboard Cite

The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single nucleotide polymorphisms (SNPs) with the lowest p-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT). Subsequently we performed sex-stratified analyses for these 1000 SNPs. Functional ex vivo studies on four genes ensued. Lastly, a look-up of GWAMA-derived BMI related loci was performed in the AN GWAMA. We detected significant associations (p-values < 5×10−5, Bonferroni corrected p < 0.05) for 9 SNP alleles at 3 independent loci. Interestingly, all AN susceptibility alleles were consistently associated with increased BMI. None of the genes (chr. 10: CTBP2, chr. 19: CCNE1, chr. 2: CARF and NBEAL1; the latter is a region with high linkage disequilibrium) nearest to these SNPs has previously been associated with AN or obesity. Sex-stratified analyses revealed that the strongest BMI signal originated predominantly from females (chr. 10 rs1561589; poverall: 2.47 × 10−06/pfemales: 3.45 × 10−07/pmales: 0.043). Functional ex vivo studies in mice revealed reduced hypothalamic expression of Ctbp2 and Nbeal1 after fasting. Hypothalamic expression of Ctbp2 was increased in diet induced obese (DIO) mice as compared to age-matched lean controls. We observed no evidence for associations for the look-up of BMI related loci in the AN GWAMA. A cross-trait analysis of AN and BMI loci revealed variants at three chromosomal loci with potential joint impact. The chromosome 10 locus is particularly promising given that the association with obesity was primarily driven by females. In addition, the detected altered hypothalamic expression patterns of Ctbp2 and Nbeal1 as a result of fasting and DIO implicate these genes in weight regulation.

show abstract

“…Expression of HOXA7 mRNA is higher in epithelial ovarian cancer than in benign tumors (10), and HOXA7 antibody in serum can be applied for diagnosis of ovarian epithelial cancer (17). HOXA7 also stimulates human hepatocellular carcinoma proliferation through regulation of cyclin E1/CDK2 (18). In addition, HOXA7 has been reported to regulate the differentiation of promyelocytic leukemia (19).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, we infer that the HOXA7 gene can serve as an independent tumor growth factor in several types of cancer. Li et al (18) have reported that HOXA7 might stimulate hepatic carcinoma by promoting the expression of cell cycle protein E1/CDK2. In addition, HOXA7 has been considered an important target for methylation, which initiates tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

The expression and significance of the <i>HOXA7</i> gene in oral squamous cell carcinoma

Duan

Chen

et al. 2017

Journal of Oral Science

View full text Add to dashboard Cite

The aim of this study was to examine the expression of HOXA7 in oral squamous cell carcinoma (OSCC) and its correlation with clinical features. Sixty tissue specimens were collected from 60 OSCC patients who underwent surgical treatment at the Stomatological Hospital affiliated to Guizhou Medical University. Sixty specimens of normal oral tissue were also collected from 60 age-and sex-matched healthy controls. Expression of HOXA7 was assessed by real time polymerase chain reaction and immunohistochemistry. Relative to the control group, HOXA7 was up-regulated in OSCC tissues at both the mRNA and protein levels (P < 0.05), and HOXA7 expression in poorly differentiated cancers was higher than that in highly differentiated cancers (P < 0.05). HOXA7 expression was higher in patients with stage III and IV cancer than in patients with stage I and II cancer (P < 0.05). Higher HOXA7 expression was also associated with the presence of vascular and nerve invasion, and lymph node and distant metastasis. HOXA7 expression in OSCC is markedly increased at both the mRNA and protein levels, and this is positively correlated with clinical stage and the degree of tumor differentiation. These data suggest that HOXA7 could serve as a diagnostic marker for OSCC or a treatment target.

show abstract

HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2

Cited by 35 publications

References 35 publications

RETRACTED ARTICLE: HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail

RETRACTED ARTICLE: HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

The expression and significance of the <i>HOXA7</i> gene in oral squamous cell carcinoma

Contact Info

Product

Resources

About