HOXA10 expression is decreased in endometrium of women with adenomyosis

Fischer, Catha; Kayisli, Umit A.; Taylor, Hillary

doi:10.1016/j.fertnstert.2010.07.693

Cited by 29 publications

(33 citation statements)

References 32 publications

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“…In some published clinical reports [7][8][9]11], adenomyosis had a detrimental effect on IVF outcome in terms of pregnancy or live birth rate, indicating impaired endometrial receptivity. In the study of Fischer et al [33], expression of the HOXA10 gene, an established marker of endometrial receptivity, was shown to be decreased in the secretory phase in the endometrium of women with adenomyosis.…”

Section: Discussionmentioning

confidence: 99%

Long-term pituitary downregulation before frozen embryo transfer could improve pregnancy outcomes in women with adenomyosis

Niu

Chen

Sun

et al. 2013

Gynecological Endocrinology

138

107

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Some studies have shown that long-term gonadotropin-releasing hormone (GnRH) agonist administration before in vitro fertilization/intracytoplasmic sperm in infertile women with endometriosis or adenomyosis significantly increases the chances of pregnancy. We were interested in whether long-term GnRH agonist pretreatment could improve pregnancy outcomes in adenomyosis patients undergoing frozen embryo transfer (FET) after preparation of the endometrium with hormone replacement therapy (HRT). Totally, 339 patients with adenomyosis were included in this retrospective study, 194 received long-term GnRH agonist plus HRT (down-regulation + HRT) and 145 received HRT. There were no differences between the groups in characteristic such as age, body mass index, duration or cause of infertility, serum CA-125 level and basal hormone levels. On the day of progesterone administration, mean endometrial thickness and serum progesterone level were significantly greater in HRT patients. Mean score and number of embryos transferred showed no differences. In down regulation + HRT group, clinical pregnancy, implantation and ongoing pregnancy rates were 51.35%, 32.56% and 48.91%, respectively, significantly higher than that of HRT group (24.83%, 16.07% and 21.38%, respectively). So, we concluded that in FET, long-term GnRH agonist pretreatment significantly improved pregnancy outcomes in patients with adenomyosis.

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Section: Discussionmentioning

confidence: 99%

Long-term pituitary downregulation before frozen embryo transfer could improve pregnancy outcomes in women with adenomyosis

Niu

Chen

Sun

et al. 2013

Gynecological Endocrinology

138

107

View full text Add to dashboard Cite

show abstract

“…The Hoxa11 −/− mice showed a more severe phenotype than the Hoxa10 −/− mice . In humans, it also was reported that the expressions of Hoxa10 and Hoxa11 in the endometrium increased significantly in the mid‐luteal phase, when the uterus is receptive to embryo attachment, and that these expressions were significantly lower in infertile women …”

Section: Molecular Mechanisms Of Decidualizationmentioning

confidence: 92%

“…84 In humans, it also was reported that the expressions of Hoxa10 and Hoxa11 in the endometrium increased significantly in the mid-luteal phase, when the uterus is receptive to embryo attachment, 88,89 and that these expressions were significantly lower in infertile women. [89][90][91][92] The BMPs belong to the transforming growth factor-beta superfamily of growth modulators 93 and transcripts that correspond to several BMP family members are expressed in mouse uteri. 94,95 In all the expressed BMPs in the uteri, only BMP2 was induced in response to P4, with intense expression in the SCs surrounding the implanted embryo.…”

Section: Molecul Ar Mechanis Ms Of Decidualiz Ationmentioning

confidence: 99%

Molecular mechanisms of embryonic implantation in mammals: Lessons from the gene manipulation of mice

Namiki

Ito

Kashiwazaki

2018

Reprod Medicine & Biology

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BackgroundHuman infertility has become a serious and social issue all over the world, especially in developed countries. Numerous types of assisted reproductive technology have been developed and are widely used to treat infertility. However, pregnancy outcomes require further improvement. It is essential to understand the cross‐talk between the uterus (mother) and the embryo (fetus) in pregnancy, which is a very complicated event.MethodsThe mammalian uterus requires many physiological and morphological changes for pregnancy‐associated events, including implantation, decidualization, placentation, and parturition, to occur. Here is discussed recent advances in the knowledge of the molecular mechanisms underlying these reproductive events — in particular, embryonic implantation and decidualization — based on original and review articles.Main findings (Results)In mice, embryonic implantation and decidualization are regulated by two steroid hormones: estrogen and progesterone. Along with these hormones, cytokines, cell‐cycle regulators, growth factors, and transcription factors have essential roles in implantation and decidualization in mice.ConclusionRecent studies using the gene manipulation of mice have given considerable insight into the molecular mechanisms underlying embryonic implantation and decidualization. However, as most of the findings are based on mice, comparative research using different mammalian species will be useful for a better understanding of the species‐dependent differences that are associated with reproductive events, including embryonic implantation.

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“…Moreover, in the review, the authors refer to several papers that attempt to justify a possible association between adenomyosis and a lower rate of implantation (Xiao et al, 2010;Fischer et al, 2011). Fisher et al suggested that a low expression of the HOXA10 gene could be a potential mechanism of impaired implantation.…”

Section: Letter Effect Of Adenomyosis On Implantationmentioning

confidence: 99%

Effect of adenomyosis on implantation

Vila-Vives

Martínez-Conejero

Pellicer

2012

Reproductive BioMedicine Online

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HOXA10 expression is decreased in endometrium of women with adenomyosis

Abstract: HOXA10 gene expression is decreased in secretory phase endometrium of women with adenomyosis. Diminished expression of HOXA10 is a potential mechanism explaining decreased implantation observed in women with adenomyosis.

Cited by 29 publications

References 32 publications

Long-term pituitary downregulation before frozen embryo transfer could improve pregnancy outcomes in women with adenomyosis

Long-term pituitary downregulation before frozen embryo transfer could improve pregnancy outcomes in women with adenomyosis

Molecular mechanisms of embryonic implantation in mammals: Lessons from the gene manipulation of mice

Effect of adenomyosis on implantation

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