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Cited by 9 publications
(10 citation statements)
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References 8 publications
(10 reference statements)
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“…The inhibitory effect of virus on YAP activation is shown in Figure 10 . Compared with the P3 sh-Control group, the shYAP group markedly accelerates the premature senescence of NPCs by activating level of p53 and p21 which mediate cell replicative senescence (Figure 10A–10C ) [ 19 , 20 ], and this result was further confirmed by SA-β-gal staining and CCK-8 assay (Figure 11A–11C ). These results suggested that the senescence of NPCs induced by interfered Hippo pathway through YAP.…”
Section: Resultsmentioning
confidence: 83%
“…The inhibitory effect of virus on YAP activation is shown in Figure 10 . Compared with the P3 sh-Control group, the shYAP group markedly accelerates the premature senescence of NPCs by activating level of p53 and p21 which mediate cell replicative senescence (Figure 10A–10C ) [ 19 , 20 ], and this result was further confirmed by SA-β-gal staining and CCK-8 assay (Figure 11A–11C ). These results suggested that the senescence of NPCs induced by interfered Hippo pathway through YAP.…”
Section: Resultsmentioning
confidence: 83%
“…Recent studies have shown that PRDX1 regulates cell cycle by interacting with CDK4 or CDK6. 34,44 CDK4/6 and cyclin D1 regulate cell cycle transition from the G1 to S phase. 38,44 Once the expression or activity of CDK4/6 is inhibited by p16, the cell cycle is arrested, leading to cell senescence.…”
Section: Discussionmentioning
confidence: 99%
“…31 As SIRT1 and SIRT2 are paramount to regulation of DNA repair, sufficient inhibition of both proteins by BZD9L1 may impede a certain degree of DNA repair and result in cell cycle arrest. 32 The degree of DNA damage will influence the activation of cell cycle arrest, whereby S-phase arrested cells or in some circumstances cells that have exited the cell cycle will undergo onset of senescence, 33 as observed in both combined treatments (Figure 2(c)).…”
Section: Discussionmentioning
confidence: 93%