How researchers are revamping antimicrobial drugs

Savage, N. W.

doi:10.1038/d41586-020-02886-1

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…[ 2 ] Annually, drug‐resistant infections cause at least 700 000 deaths globally each year; and this number is predicted to increase to 10 million by 2050. [ 3 ] To overcome this challenge, it is imperative to offer viable options to fight against antimicrobial resistance (AMR). Among the various strategies, antibiotic‐free strategies have become a promising approach to respond to the current antibacterial dilemma.…”

Section: Introductionmentioning

confidence: 99%

pH‐Triggered Size‐Tunable Silver Nanoparticles: Targeted Aggregation for Effective Bacterial Infection Therapy

Cheng

Pei

Xie

et al. 2022

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The rapid spread of drug‐resistant pathogens threatens human health. To address the current antibacterial dilemma, the development of antibiotic‐free strategies using nanotechnology is imperative. In this study, silver nanoparticles (Ag‐P&C NPs) with pH‐sensitive charge reversal and self‐aggregation capacities are successfully synthesized. In the acidic microenvironment of bacterial biofilms, protonation of the surface peptide enhances the affinity of Ag‐P&C NPs for bacteria, which can make Ag‐P&C NPs prone to target and penetrate into biofilms, and the self‐aggregated capacity helps Ag‐P&C NPs remain in biofilms for a long time to disrupt bacterial biofilm formation. In addition, biocompatible Ag‐P&C NPs are utilized in three types of bacteria‐infected animal models. They exhibit an excellent performance in killing bacteria, inhibiting plaque biofilms, and ameliorating inflammatory responses. In conclusion, this study offers new insights into antibiotic‐free antibacterial strategies, and exhibits promising application prospects.

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Section: Introductionmentioning

confidence: 99%

pH‐Triggered Size‐Tunable Silver Nanoparticles: Targeted Aggregation for Effective Bacterial Infection Therapy

Cheng

Pei

Xie

et al. 2022

Small

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“…On the biological side, it is likely that the antibiotic boom of the 1950s–1990s was only caused by the “low-hanging fruit” nature of bacterial targets and antibiotic molecules [ 2 ]. Financially, there is stark contrast between funding, such as the Combating Antibiotic-Resistant bacteria Biopharmaceutical Accelerator and its USD 500 million to support research [ 342 ], and the USD 2.3 billion it costs to develop a new drug on average. Governmental plans to “jump-(re)start” antibiotic R&D consist mostly of giving away public monies to the same companies that are at the root of the problem.…”

Section: Non-canonical Approaches To Fight Resistant Infectionsmentioning

confidence: 99%

Non-Canonical Aspects of Antibiotics and Antibiotic Resistance

Amábile-Cuevas,

Lund-Zaina

2024

Antibiotics

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The understanding of antibiotic resistance, one of the major health threats of our time, is mostly based on dated and incomplete notions, especially in clinical contexts. The “canonical” mechanisms of action and pharmacodynamics of antibiotics, as well as the methods used to assess their activity upon bacteria, have not changed in decades; the same applies to the definition, acquisition, selective pressures, and drivers of resistance. As a consequence, the strategies to improve antibiotic usage and overcome resistance have ultimately failed. This review gathers most of the “non-canonical” notions on antibiotics and resistance: from the alternative mechanisms of action of antibiotics and the limitations of susceptibility testing to the wide variety of selective pressures, lateral gene transfer mechanisms, ubiquity, and societal factors maintaining resistance. Only by having a “big picture” view of the problem can adequate strategies to harness resistance be devised. These strategies must be global, addressing the many aspects that drive the increasing prevalence of resistant bacteria aside from the clinical use of antibiotics.

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“…These phytoconstituents or SMs are non-hazardous, eco-friendly, and are widely known for their innumerable applications for example nutraceuticals, agriculture, perfumery, personal hygiene, pharmaceutical and cosmeceutical [ [1] , [2] , [3] , [4] , [5] , [6] ]. In order to counter the problem of resistance produced by the present antiviral and antibacterial drugs and owing to the toxic nature of most of synthetic antioxidants or preservatives, from precedent decade, the extensive search for plant based novel antibacterial, antiviral and antioxidants agents is underway [ [7] , [8] , [9] , [10] , [11] ]. Therefore, in the coming future there are innumerable projections to pursuit for the diverse array of natural bioactive antibacterial, antiviral and antioxidant agents of plant origin [ [12] , [13] , [14] ].…”

Section: Introductionmentioning

confidence: 99%

Greener approach for the isolation of oleanolic acid from Nepeta leucophylla Benth. Its derivatization and their molecular docking as antibacterial and antiviral agents

Sharma¹,

Kathuria²,

Kolita³

et al. 2023

Heliyon

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How researchers are revamping antimicrobial drugs

Abstract: is rethinking ways to search for drug candidates that overcome drug resistance. KELVIN MA/TUFTS UNIV.

Cited by 6 publications

References 5 publications

pH‐Triggered Size‐Tunable Silver Nanoparticles: Targeted Aggregation for Effective Bacterial Infection Therapy

pH‐Triggered Size‐Tunable Silver Nanoparticles: Targeted Aggregation for Effective Bacterial Infection Therapy

Non-Canonical Aspects of Antibiotics and Antibiotic Resistance

Greener approach for the isolation of oleanolic acid from Nepeta leucophylla Benth. Its derivatization and their molecular docking as antibacterial and antiviral agents

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