How REM sleep deprivation and amantadine affects male rat sexual behavior

Ferraz, Marcos Rochedo; Ferraz, Marcia Martins Dias; Santos, R. F.

doi:10.1016/s0091-3057(01)00508-1

Cited by 29 publications

(25 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other symptoms include increased heart rate [33]. Apart from that, hypersexuality has also been observed in rats [46,47]. During the rebound IJOMEH 2010;23(1) 100 of work performance as well as impaired cognitive processing.…”

Section: Post-deprivation Recovery: Rebound Sleepmentioning

confidence: 99%

Consequences of sleep deprivation

Orzeł-Gryglewska¹

2010

International Journal of Occupational Medicine and Environmental Health

211

133

View full text Add to dashboard Cite

This paper presents the history of research and the results of recent studies on the effects of sleep deprivation in animals and humans. Humans can bear several days of continuous sleeplessness, experiencing deterioration in wellbeing and effectiveness; however, also a shorter reduction in the sleep time may lead to deteriorated functioning. Sleeplessness accounts for impaired perception, difficulties in keeping concentration, vision disturbances, slower reactions, as well as the appearance of microepisodes of sleep during wakefulness which lead to lower capabilities and efficiency of task performance and to increased number of errors. Sleep deprivation results in poor memorizing, schematic thinking, which yields wrong decisions, and emotional disturbances such as deteriorated interpersonal responses and increased aggressiveness. The symptoms are accompanied by brain tissue hypometabolism, particularly in the thalamus, prefrontal, frontal and occipital cortex and motor speech centres. Sleep deficiency intensifies muscle tonus and coexisting tremor, speech performance becomes monotonous and unclear, and sensitivity to pain is higher. Sleeplessness also relates to the changes in the immune response and the pattern of hormonal secretion, of the growth hormone in particular. The risk of obesity, diabetes and cardiovascular disease increases. The impairment of performance which is caused by 20-25 hours of sleeplessness is comparable to that after ethanol intoxication at the level of 0.10% blood alcohol concentration. The consequences of chronic sleep reduction or a shallow sleep repeated for several days tend to accumulate and resemble the effects of acute sleep deprivation lasting several dozen hours. At work, such effects hinder proper performance of many essential tasks and in extreme situations (machine operation or vehicle driving), sleep loss may be hazardous to the worker and his/her environment.

show abstract

Section: Post-deprivation Recovery: Rebound Sleepmentioning

confidence: 99%

Consequences of sleep deprivation

Orzeł-Gryglewska¹

2010

International Journal of Occupational Medicine and Environmental Health

211

133

View full text Add to dashboard Cite

show abstract

“…The method of REMD used in this study was modified from Ferraz's version of the water platform technique (Ferraz et al 2001). The technique takes advantage of the fact that an animal entering REM sleep loses its postural control due to decreased muscle tone.…”

Section: Rapid Eye Movement Sleep Deprivationmentioning

confidence: 99%

Wake-promoting agent modafinil worsened attentional performance following REM sleep deprivation in a young-adult rat model of 5-choice serial reaction time task

Liu¹,

Tung²,

Lin³

et al. 2010

Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Contributing to the initiation factor are the mount and intromission latencies; contributing to the intromission count factor is the intromission number; contributing to the hit rate factor is the copulatory efficiency; and contributing to the copulatory rate factor are ejaculation latency and postejaculatory interval [26][27][28]. Thus, mount and intromission latencies allow the evaluation of the sexual response arousal component.…”

Section: Discussionmentioning

confidence: 99%

“…The intromission number and the copulatory efficiency allow evaluation of the erectile response. The ejaculatory latency and postejaculatory interval allow the evaluation of the ejaculatory component of sexual behavior [28]. Therefore, each component of the male rat sexual response can be evaluated independently from the others.…”

Section: Discussionmentioning

confidence: 99%

Effect of novel synthetic evodiamine analogue on sexual behavior in male rats

Vyawahare¹,

Hadambar²,

Chothe³

et al. 2011

J Chem Biol

View full text Add to dashboard Cite

Currently phosphodiestrase5 (PDE5) inhibitors are the first-line treatment for erectile dysfunction. Drugs such as sildenafil and tadalafil are available as PDE5 inhibitors which are potent and reversible but lack selectivity with side effects such as headache, facial flushing, dyspepsia, and visual disturbances. We herein report for the first time novel condensed thienopyrimidines as evodiamine analogue and their effect on sexual behavior in male rats hitherto unreported. Novel synthetic evodiamine significantly showed improvement in male rat copulatory behavior. The test compound MKAC9 could be of promising importance in the treatment of sexual disorders like desire disorder or erectile dysfunction.

show abstract

How REM sleep deprivation and amantadine affects male rat sexual behavior

Cited by 29 publications

References 28 publications

Consequences of sleep deprivation

Consequences of sleep deprivation

Wake-promoting agent modafinil worsened attentional performance following REM sleep deprivation in a young-adult rat model of 5-choice serial reaction time task

Effect of novel synthetic evodiamine analogue on sexual behavior in male rats

Contact Info

Product

Resources

About