How rare is melanoacanthoma?

Simon, P.

doi:10.1001/archderm.127.4.583

Cited by 9 publications

(7 citation statements)

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“…Only scattered reports exist on melanoacanthoma of the external ear and oral cavity 12 13 14 15 16 . In agreement with the present study, the findings of Simón et al 17 refuted claims that melanoacanthoma is extremely rare; the group used Fontana-Masson silver impregnation to stain 189 samples from cases of SK and observed that 28% (53 cases) fulfilled the diagnostic requirements for melanoacanthoma. Hence, it seems that salient proliferation of dendritic melanocytes is not rare in SK.…”

Section: Discussionsupporting

confidence: 92%

Clinical and Histopathological Investigation of Seborrheic Keratosis

et al. 2016

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BackgroundSeborrheic keratosis (SK) is one of the most common epidermal tumors of the skin. However, only a few large-scale clinicohistopathological investigations have been conducted on SK or on the possible correlation between histopathological SK subtype and location.ObjectiveThe aim of this study was to analyze the clinical and histopathological features of a relatively large number of cases of diagnosed SK.MethodsTwo hundred and seventy-one pathology slides of skin tissue from patients with clinically diagnosed SK and 206 cases of biopsy-proven SK were analyzed. The biopsy-proven cases of SK were assessed for histopathological subclassification. The demographic, clinical, and histopathological data of the patients were collected for analysis of associated factors.ResultsThe most frequent histopathological subtype was the acanthotic type, followed by mixed, hyperkeratotic, melanoacanthoma, clonal, irritated, and adenoid types; an unexpectedly high percentage (9.2%) of the melanoacanthoma variant was observed. The adenoid type was more common in sun-exposed sites than in sun-protected sites (p=0.028). Premalignant and malignant entities together represented almost one-quarter (24.2%) of the clinicopathological mismatch cases (i.e., mismatch between the clinical and histopathological diagnoses). Regarding the location of SK development, the frequency of mismatch for the sun-exposed areas was significantly higher than that for sun-protected areas (p=0.043).ConclusionThe adenoid type was more common in sun-exposed sites. Biopsy sampling should be performed for lesions situated in sun-exposed areas to exclude other premalignant or malignant diseases.

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Section: Discussionsupporting

confidence: 92%

Clinical and Histopathological Investigation of Seborrheic Keratosis

et al. 2016

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“…Electron microscopic studies reveal large highly dendritic melanocytes with abundant melanin granules in epidermis 5 . Some authors suggest that melanoacanthoma does not deserve a special denomination because the presence of a striking number of dendritic melanocytes at suprabasal levels is a frequent finding in every type of seborrheic keratosis, other than of the reticulated type 6 . However like most authors, we consider melanoacanthoma to be a clinically and histologically distinct entity [1][2][3]5 .…”

Section: Discussionmentioning

confidence: 99%

A Case of Melanoacanthoma: Immunohistochemical Staining Using VECTOR® NovaRED(TM) to Distinguish Melanocytes from the Cutaneous Pigment

et al. 2008

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Melanoacanthoma is a rare benign mixed tumor of both keratinocytes and melanocytes.Although some authors said that it is a rare variant of seborrheic keratosis, it has clinical and histological features distinct from seborrheic keratosis. It has large dendritic melanin-laden melanocytes throughout all levels of epidermis showing a disruption of melanin transfer from the melanocytes to neighboring keratinocytes. However, it is difficult to distinguish melanocytes clearly from cutaneous pigment in immunohistochemical stain with usually used brown chromogen. We used chromogen with brick-red indicator product (VECTOR Ⓡ NovaRED TM ) in S-100 and melan-A immunohistochemical staining to distinguish melanocytes from melanin laden keratinocytes. We suggest that the immunohistochemical staining using this novel chromogen may be useful in the diagnosis of melanoacanthoma. (Ann Dermatol (Seoul) 20(1) 18∼21, 2008)

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“…Melanoacanthoma has been described once previously on the eyelid, occurring in a 40‐year‐old black man as multiple, minute, individual and confluent, dark, shiny papules limited in distribution to the left upper eyelid 3 . Cutaneous melanoacanthoma is usually evident as a single, pigmented, verrucous, round or oval plaque with a diameter ranging from a few millimeters to 10 cm 4–14 . Cutaneous melanoacanthomas are mainly found on the head, particularly the lips, and the trunk.…”

Section: Discussionmentioning

confidence: 99%

“…Although Prince et al 7 . described it in only five cases amongst 500,000 consecutive skin biopsies, Simón et al 10 . noted its suprabasalar features in 28% of 189 consecutive cases of seborrheic keratosis.…”

Section: Discussionmentioning

confidence: 99%

Giant cutaneous melanoacanthoma

et al. 2004

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A 45‐year‐old male cook was seen for the evaluation and removal of a “mole on my eye” of steady growth during the previous 6 months. The patient stated that he had had a “brown spot” above his left eye for 17 years prior to its recent enlargement; it was now partly blocking the vision in his left eye. He denied a history or family history of cutaneous tumors, including skin cancer. On examination, a 2.5‐cm × 0.5‐cm × 0.8‐cm, horn‐like, darkly pigmented, cutaneous nodule was evident extending from the left upper eyelid downwards to below the lower eyelid (Figs 1 and 2). He also had scattered, skin‐colored, 2–3‐mm cystic papules on his anterior mid‐chest. A shave excision specimen was obtained from the eyelid nodule. 1 Horn‐like, cutaneous nodule extending from the left upper eyelid downwards to below the lower eyelid 2 Close up, demonstrating the morphologic features to better advantage Microscopic examination demonstrated acanthosis, hyperkeratosis, and papillomatosis (Fig. 3). Large dendritic cells with abundant melanin granules were spread throughout the epidermis. In addition, small basaloid or spinous keratinocytes were present in the malpighian layer. 3 Histology of the nodule, showing an epidermis with acanthosis, hyperkeratosis, papillomatosis, and large dendritic cells with abundant melanin granules spread throughout the epidermis (hematoxylin and eosin; original magnification, × 100)

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How rare is melanoacanthoma?

Cited by 9 publications

References 0 publications

Clinical and Histopathological Investigation of Seborrheic Keratosis

Clinical and Histopathological Investigation of Seborrheic Keratosis

A Case of Melanoacanthoma: Immunohistochemical Staining Using VECTOR® NovaRED(TM) to Distinguish Melanocytes from the Cutaneous Pigment

Giant cutaneous melanoacanthoma

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