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citations
Cited by 281 publications
(126 citation statements)
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References 12 publications
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“…Sizes of PCR products are indicated. M, FX174/HaeIII digest; +RT, reverse transcription performed in the presence of reverse transcriptase; 7RT, mock reverse transcription performed without reverse transcriptase; 7ve, PCR set up without DNA; +ve, PCR set up using genomic DNA (Fields et al, 1994) are present within the human haploid genome of 3000 Mb, giving an average gene density of approximately 23 genes per megabase. However, genes are non-randomly distributed within the genome between gene poor Giemsa dark bands, gene rich R'-bands and very gene rich sub-telomeric Tbands which are estimated to contain 9.3, 20 and 78 genes/Mb respectively (Bernardi, 1993).…”
Section: Discussionmentioning
confidence: 99%
“…Sizes of PCR products are indicated. M, FX174/HaeIII digest; +RT, reverse transcription performed in the presence of reverse transcriptase; 7RT, mock reverse transcription performed without reverse transcriptase; 7ve, PCR set up without DNA; +ve, PCR set up using genomic DNA (Fields et al, 1994) are present within the human haploid genome of 3000 Mb, giving an average gene density of approximately 23 genes per megabase. However, genes are non-randomly distributed within the genome between gene poor Giemsa dark bands, gene rich R'-bands and very gene rich sub-telomeric Tbands which are estimated to contain 9.3, 20 and 78 genes/Mb respectively (Bernardi, 1993).…”
Section: Discussionmentioning
confidence: 99%
“…areas of the cerebral cortex), posing a significant challenge to creating a unified resource such as the connectome. Noteworthy is the fact that in the early days of genomics the number and boundaries of genes was not clear either and that actually genomics technology helped to define them (Fields et al, 1994). In the human cerebral cortex, neurons are arranged in an unknown number of anatomically distinct regions and areas, perhaps on the order of 100 or more.…”
Section: From Tracts To Network 231 Past and Current State Of Thementioning
confidence: 99%
“…Before the completion of the human genome, gene estimates were in the range of w70 000 for humans (G20 000) and w20 000 for invertebrates [12][13][14]. This fourfold difference and the observed 1:4 relationship between many Drosophila and human genes (1:4 rule) [15][16][17] was an additional argument in favor of two rounds of WGD under the assumption that no subsequent gene loss had happened.…”
Section: Introductionmentioning
confidence: 98%