DOI: 10.1016/j.clnesp.2016.02.004
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Abstract: Objectives: Postoperative ileus is a common complication after colorectal resection. Targinact combines oral oxycodone with naloxone and may reduce opiate-induced gut dysfunction after colorectal surgery. We examined the feasibility of a randomised trial of Targinact within the context of an enhanced recovery (ER) perioperative protocol for laparoscopic colorectal resection in an NHS setting. Methods: This was a single-centre open-label phase II feasibility study. Patients were recruited and randomised to rece…

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