How Error Correction Affects PCR Deduplication: A Survey Based on UMI Datasets of Short Reads
Pengyao Ping,
Tian Lan,
Shuquan Su
et al.
Abstract:Next-Generation Sequencing (NGS) data is widely utilised for various downstream applications in bioinformatics, and numerous techniques have been developed forPCR-deduplicationanderror-correctionto eliminate bias and errors introduced during the sequencing. This study first-time provides a joint overview of recent advances in PCR-deduplication and error-correction on short reads. In particular, we utilise UMI-based PCR-deduplication strategies and sequencing data to assess the performance of the solely-computa… Show more
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