volume 1864, issue 1, P129456 2020
DOI: 10.1016/j.bbagen.2019.129456
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A. Haimovich, A. Goldbourt

Abstract: Lithium, in the form of a salt, is a mood stabilizer and a leading drug for the treatment of bipolar disorder. It has a very narrow therapeutic range and a variety of side effects. Lithium can replace magnesium and other cations in enzymes and small molecules, among them ATP, thereby affecting and inhibiting many biochemical pathways. The form of binding of lithium ions to ATP is not known.Here we extract the binding environment of lithium in solid ATP using a multi-nuclear multi-dimensional solid-state NMR ap…

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