How Does Amniotic Membrane Work?

Tseng, Scheffer C.G.; Espana, Edgar M.; Kawakita, Tetsuya; Pascuale, Mario A. Di; Li, Wei; He, Hua; Liu, Tzong Shyne; Cho, Tae-Hee; Gao, Yingying; Yeh, Lung‐Kun; Liu, Chia-Yang

doi:10.1016/s1542-0124(12)70059-9

Cited by 269 publications

(219 citation statements)

References 74 publications

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“…This novel approach was derived from the clinical experiences in transplanting cryopreserved human amniotic membrane, i.e., the innermost layer of the placenta, to facilitate ocular surface reconstruction (for reviews see [90][91][92][93][94]). Many diverse action mechanisms have been ascribed to the amniotic membrane for its supplanting with a new basement membrane and a stroma that can suppress inflammation, scarring and angiogenesis (for review see [95]). Importantly, amniotic membrane transplantation alone is sufficient to restore the normal corneal epithelial phenotype in human corneas with partial limbal SC deficiency [96][97][98], indicating that amniotic membrane helps expand residual limbal epithelial SCs in vivo.…”

Section: Will Restoration Of Niche Support Be Critical For Ex Vivo Exmentioning

confidence: 99%

Niche regulation of corneal epithelial stem cells at the limbus

et al. 2007

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Among all adult somatic stem cells, those of the corneal epithelium are unique in their exclusive location in a defined limbal structure termed Palisades of Vogt. As a result, surgical engraftment of limbal epithelial stem cells with or without ex vivo expansion has long been practiced to restore sights in patients inflicted with limbal stem cell deficiency. Nevertheless, compared to other stem cell examples, relatively little is known about the limbal niche, which is believed to play a pivotal role in regulating self-renewal and fate decision of limbal epithelial stem cells. This review summarizes relevant literature and formulates several key questions to guide future research into better understanding of the pathogenesis of limbal stem cell deficiency and further improvement of the tissue engineering of the corneal epithelium by focusing on the limbal niche.

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Section: Will Restoration Of Niche Support Be Critical For Ex Vivo Exmentioning

confidence: 99%

Niche regulation of corneal epithelial stem cells at the limbus

et al. 2007

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“…Tseng et al 20 reported that the anti-inflammatory activity of the HAM requires a close contact with its stromal matrix. The high content of proteoglycans and glycoproteins of the intermediate layer of the stromal matrix contains a non-fibrillar mesh, mainly of type III collagen 6 .…”

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confidence: 99%

Effects of the application of the amniotic membrane in the healing process of skin wounds in rats

et al. 2018

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1 AbstractPurpose: To evaluate the efficacy of the application of the human amniotic membrane (HAM) on the inflammatory process, fibroblast proliferation, formation of collagenand reduction of skin wound areas in rats. Methods: Thirty six rats were submitted to a surgical injury induction and divided into two groups (n = 18): group C (control) and T (treated with the HAM). The macroscopic evolution in the wound area and the histological characteristics of the skin samples were evaluated. Results: The regression of the wound area was greater in group T. The histological analysis revealed a significant reduction (p < 0.05) in the inflammatory infiltrate in group T at all experimental periods compared with that in the control group. Furthermore, the group T presented a significant increase in the proliferation of fibroblasts at 14 and 21 days compared with group C (p < 0.05). Regarding the deposition of mature collagen fibers, there was an increase in the replacement of type III collagen by type I collagen in group T (p < 0.05). Conclusion: Treatment with the HAM reduced the healing time as well as the inflammatory responses, increased the proliferation of fibroblasts, and induced a higher concentration of mature collagen fibers.

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“…The majority of the studies testify the clinical efficacy of amniotic membrane transplantation (AMT) in gearing adult wound healing toward regeneration with minimal inflammation and scarring, suggesting that amniotic membrane (AM), like the fetal tissue, carries similar features that may not only facilitate regeneration but also inhibit scar formation (Mast et al, 1992;Adzick and Lorenz, 1994) A number of mechanisms have been put forth to explain the AM's biological actions in modulating adult wound healing toward the fetal direction with anti-inflammation, antiscarring and anti-angiogenesis. (Tseng et al, 2004). It remains unclear whether such therapeutic actions are directly or indirectly linked to modulate healing and differentiation.…”

Section: Fetal Strategy Of Wound Healingmentioning

confidence: 99%

Update on Modulating Wound Healing in Trabeculectomy

Sheha¹

2011

Glaucoma - Basic and Clinical Concepts

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How Does Amniotic Membrane Work?

Cited by 269 publications

References 74 publications

Niche regulation of corneal epithelial stem cells at the limbus

Niche regulation of corneal epithelial stem cells at the limbus

Effects of the application of the amniotic membrane in the healing process of skin wounds in rats

Update on Modulating Wound Healing in Trabeculectomy

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