How Do We Define Cure of Diabetes?

Buse, John B.; Caprio, Sonia; Cefalu, William T.; Ceriello, Antonio; Prato, Stefano Del; Inzucchi, Silvio E.; McLaughlin, Sue; Phillips, Gordon L.; Robertson, R. P.; Rubino, Francesco; Kahn, Richard; Kirkman, M. Sue

doi:10.2337/dc09-9036

Cited by 882 publications

(616 citation statements)

References 3 publications

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“…Investigating whether outcomes differ between men and women is import in developing gender‐specific treatment programmes, if required 6, 7, 8, 9, 10, 11, 12. Differences in outcome after weight loss have been reported previously, with men commonly losing more body weight and fat than women 13.…”

Section: Introductionmentioning

confidence: 94%

Men and women respond differently to rapid weight loss: Metabolic outcomes of a multi‐centre intervention study after a low‐energy diet in 2500 overweight, individuals with pre‐diabetes (PREVIEW)

Christensen

Larsen

Westerterp-Plantenga

et al. 2018

Diabetes Obesity Metabolism

122

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AimsThe PREVIEW lifestyle intervention study (http://clinicaltrials.gov Identifier: NCT01777893) is, to date, the largest, multinational study concerning prevention of type‐2 diabetes. We hypothesized that the initial, fixed low‐energy diet (LED) would induce different metabolic outcomes in men vs women.Materials and methodsAll participants followed a LED (3.4 MJ/810 kcal/daily) for 8 weeks (Cambridge Weight Plan). Participants were recruited from 8 sites in Europe, Australia and New Zealand. Those eligible for inclusion were overweight (BMI ≥ 25 kg/m2) individuals with pre‐diabetes according to ADA‐criteria. Outcomes of interest included changes in insulin resistance, fat mass (FM), fat‐free mass (FFM) and metabolic syndrome Z‐score.ResultsIn total, 2224 individuals (1504 women, 720 men) attended the baseline visit and 2020 (90.8%) completed the follow‐up visit. Following the LED, weight loss was 16% greater in men than in women (11.8% vs 10.3%, respectively) but improvements in insulin resistance were similar. HOMA‐IR decreased by 1.50 ± 0.15 in men and by 1.35 ± 0.15 in women (ns). After adjusting for differences in weight loss, men had larger reductions in metabolic syndrome Z‐score, C‐peptide, FM and heart rate, while women had larger reductions in HDL cholesterol, FFM, hip circumference and pulse pressure. Following the LED, 35% of participants of both genders had reverted to normo‐glycaemia.ConclusionsAn 8‐week LED induced different effects in women than in men. These findings are clinically important and suggest gender‐specific changes after weight loss. It is important to investigate whether the greater decreases in FFM, hip circumference and HDL cholesterol in women after rapid weight loss compromise weight loss maintenance and future cardiovascular health.

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Section: Introductionmentioning

confidence: 94%

Men and women respond differently to rapid weight loss: Metabolic outcomes of a multi‐centre intervention study after a low‐energy diet in 2500 overweight, individuals with pre‐diabetes (PREVIEW)

Christensen

Larsen

Westerterp-Plantenga

et al. 2018

Diabetes Obesity Metabolism

122

View full text Add to dashboard Cite

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“…The term "optimization" was used as this study did not include the one-year laboratory data to meet the definition of "partial diabetes remission" proposed by Buse et al [12].…”

Section: Variablesmentioning

confidence: 99%

A 12-Week Low-Calorie Diet plus Behavioral Modification Acutely Improves Glycemic Parameters in Type 2 Diabetes Mellitus

Forney¹,

Moore²,

Dong

et al. 2014

J Obes Weight Loss Ther

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“…However, the definition of T2DM remission varies among the studies. In order to standardize the definition of complete remission of T2DM after bariatric surgery, ADA suggested definition based on return to "normal" measures of glucose metabolism (HbA1c in the normal range, fpG <5.7 mmol/L) of at least 1-year duration without medication or ongoing procedures (22). pournaras et al (23) compared T2DM remission rate after gastric bypass with a median of 2 years of follow-up based on new ADA and previous definitions and found that it was significantly lower with new definition (40.6% vs 57.5%; p = 0.003).…”

Section: Surgery Versus Conventional Treatmentmentioning

confidence: 99%

Surgery in the treatment of type 2 diabetes mellitus

et al. 2015

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Background and Aims: the prevalence of diabetes is increasing worldwide, and most of the cases are type 2 diabetes mellitus. the relationship between type 2 diabetes mellitus and obesity is well established, and surgical treatment is widely used for obese patients with type 2 diabetes mellitus. the aim was to present current knowledge about the possible mechanisms responsible for glucose control after surgical procedures and to review the surgical treatment results.Material and Methods: medical literature was searched for the articles presenting the impact of surgical treatment on glycemic control, long-term results, and possible mechanisms of action among obese individuals with type 2 diabetes mellitus.Results: remission of type 2 diabetes mellitus after bariatric surgery depends on the definition of the remission used. complete remission rate after surgery with the new criteria is lower than was considered before. randomized controlled studies demonstrate that surgery is superior to best medical treatment for the patients with type 2 diabetes mellitus. the recurrence of type 2 diabetes mellitus after bariatric surgery is observed in up to 40% of cases with ≥5 years of follow-up. despite the recurrence of type 2 diabetes mellitus in this group, better glycemic control and lower risk of macrovascular complications are present. incretin effects on glycemic control after bariatric surgery are well described, but the role of other possible mechanisms (bile acids, microbiota, intestinal gluconeogenesis) in humans is unclear.Conclusion: Surgery is an effective treatment of type 2 diabetes mellitus in obese patients. the most optimal surgical procedure for the treatment of obese patients with type 2 diabetes mellitus is still to be established. more research is needed to explore the mechanisms of glycemic control after bariatric surgery.

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How Do We Define Cure of Diabetes?

Cited by 882 publications

References 3 publications

Men and women respond differently to rapid weight loss: Metabolic outcomes of a multi‐centre intervention study after a low‐energy diet in 2500 overweight, individuals with pre‐diabetes (PREVIEW)

Men and women respond differently to rapid weight loss: Metabolic outcomes of a multi‐centre intervention study after a low‐energy diet in 2500 overweight, individuals with pre‐diabetes (PREVIEW)

A 12-Week Low-Calorie Diet plus Behavioral Modification Acutely Improves Glycemic Parameters in Type 2 Diabetes Mellitus

Surgery in the treatment of type 2 diabetes mellitus

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