2012
DOI: 10.1002/biot.201200226
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Abstract: This report highlights the potential of measurement, monitoring, modeling and control (M(3) C) methodologies in animal and human cell culture technology. In particular, state-of-the-art of M(3) C technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in M(3) C are discussed from a cell culture perspective for industrial pro… Show more

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Cited by 51 publications
(40 citation statements)
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“…The US Food and Drug Administration advises (bio)pharmaceutical companies to use process analytical technology (PAT) for better control of bioprocesses in order to consistently deliver high quality products . In applications of PAT to cell cultivation processes, parameters are often controlled using data from well‐established classical sensors such as glass electrodes for pH, thermocouples for temperature or Clark electrodes for dissolved oxygen . Solutions for real‐time monitoring of other relevant analytes such as concentrations of cells, main nutrients, and metabolic by‐products (glucose, glutamine, lactate, etc.)…”
Section: Introductionmentioning
confidence: 99%
“…The US Food and Drug Administration advises (bio)pharmaceutical companies to use process analytical technology (PAT) for better control of bioprocesses in order to consistently deliver high quality products . In applications of PAT to cell cultivation processes, parameters are often controlled using data from well‐established classical sensors such as glass electrodes for pH, thermocouples for temperature or Clark electrodes for dissolved oxygen . Solutions for real‐time monitoring of other relevant analytes such as concentrations of cells, main nutrients, and metabolic by‐products (glucose, glutamine, lactate, etc.)…”
Section: Introductionmentioning
confidence: 99%
“…It has been stressed by [48][49][50] that mathematical modeling is a substantial part of QbD since the model contributes to a scientific understanding on the product formation and the process control and monitoring. However, the performance of a model structure is highly dependent on the identification of key parameters.…”
Section: Modelingmentioning
confidence: 99%
“…The impact of Systems Biology in biotechnological processes is so great that the term "industrial systems biology" is today very common within this kind of industries [1,2]. Measurement, monitoring, modelling and control (the so-called M3C methodology) are critical for obtaining high value-added biochemicals [3].…”
Section: Introductionmentioning
confidence: 99%